Birth prevalence of cryptorchidism and hypospadias in northern England, 1993-2000
Birth prevalence of cryptorchidism and hypospadias in northern England, 1993-2000
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DOI：
10.1136/adc.2006.102913
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发表时间：
2007-07-01
影响因子：
5.2
通讯作者：
McNally, R. J. Q.
中科院分区：
文献类型：
--
作者：
Abdullah, N. A.;Pearce, M. S.;McNally, R. J. Q.
目的：隐睾症和尿道下裂的患病率是否在增加存在很大争议。为了解决这一问题，我们调查了1993- 2000年期间英国北方地区隐睾和尿道下裂的出生患病率。方法：隐睾和尿道下裂病例来自北方地区医院病例统计（HES）。出生患病率的趋势，男性活产的数量的基础上，进行了评估，使用线性regression.Results：患病率为7.6每1000名男性活产隐睾和3.1每1000名男性活产尿道下裂。0-4奥尔兹和5-14岁儿童的脊柱固定率分别为每1000名男性人口1.8和0.8人。0-4奥尔兹和5- 14岁男性尿道下裂修复率分别为0.6/1000和0.1/1000。每年每1000名5岁以下男性人群中隐睾矫正手术的发生率为0.1例，呈统计学显著下降趋势（95%置信区间：20.01至20.05，p，0.001），但尿道下裂矫正手术无时间变化（p = 0.60）。结论：研究期间的HES数据质量较高。手术矫正尿道下裂的患病率没有显着变化。然而，手术矫正隐睾的患病率明显下降，这可能反映了该疾病患病率的下降，也可能是由于手术干预率的下降。
Aim: There is much debate as to whether the prevalence rates of cryptorchidism and hypospadias are increasing. To address this issue we investigated the birth prevalence of cryptorchidism and hypospadias in the northern region of England during the period 1993-2000.Methods: Cases of cryptorchidism and hypospadias were identified from northern region hospital episodes statistics (HES). Trends in birth prevalence, based on the number of male live births, were assessed using linear regression.Results: Prevalence was 7.6 per 1000 male live births for cryptorchidism and 3.1 per 1000 male live births for hypospadias. The orchidopexy rates for 0-4 year olds and 5-14 year olds were 1.8 and 0.8 per 1000 male population, respectively. The rates for hypospadias repair for 0-4 year olds and 5- 14 year olds were 0.6 and 0.1 per 1000 male population, respectively. There was a statistically significant decreasing temporal trend for the corrective procedure in cryptorchidism of 0.1 per 1000 male population aged under 5 years per annum (95% confidence interval: 20.01 to 20.05, p, 0.001), but no temporal change for the corrective procedure in hypospadias ( p = 0.60).Conclusion: HES data were of high quality for the study period. There was no significant change in the prevalence of surgically corrected hypospadias. However, there was an apparent decline in the prevalence of surgically corrected cryptorchidism that may reflect a decrease in the prevalence of the condition or may be due to a decrease in the rate of surgical intervention.