HOMOLOGIES AND ANOMALIES IN PRIMARY STRUCTURAL PATTERNS OF NUCLEOTIDE BINDING-PROTEINS
HOMOLOGIES AND ANOMALIES IN PRIMARY STRUCTURAL PATTERNS OF NUCLEOTIDE BINDING-PROTEINS
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DOI：
10.1111/j.1432-1033.1985.tb09244.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
LEBERMAN, R
中科院分区：
文献类型：
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作者：
ARGOS, P;LEBERMAN, R
在寻找核苷酸结合蛋白之间的同源性时，最近的报道已经描述了包括ras和src癌基因产物在内的各种蛋白质之间30个左右氨基酸残基的一级结构比对。这些序列匹配的意义已经通过在可用的数据库中搜索由比对产生的某些保守残基模式进行了测试。这些测试表明，在这些有限的拉伸比对不一定是合理的，任何涉及核苷酸结合的残基的影响必须谨慎看待。
In searches for homology among nucleotide binding proteins, recent reports have described primary structure alignments for stretches of 30 or so amino acid residues among a variety of proteins including the ras and src oncogene products. The significance of these sequence matches has been tested by searching in available data-banks for certain conserved residue patterns resulting from the alignments. The tests suggest that alignments over these limited stretches are not necessarily justifiable and any implications for residues involved in nucleotide binding must be viewed with caution.