Longitudinal optical imaging study for locomotor recovery after stroke
Longitudinal optical imaging study for locomotor recovery after stroke
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DOI：
10.1161/01.str.0000100166.81077.8a
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发表时间：
2003-12-01
期刊：
影响因子：
8.3
通讯作者：
Kubota, K
中科院分区：
文献类型：
--
作者：
Miyai, I;Yagura, H;Kubota, K
背景和目的：我们试图研究脑卒中后运动恢复的大脑机制。方法：我们使用光学成像系统测量了8例初次中风患者（5男3女，4右4左，年龄57岁，平均中风后3个月）住院康复前后在跑步机上偏瘫步态时的皮质活动。结果-在初步评估中，偏瘫步态与内侧初级感觉运动皮层（SMC）的氧合血红蛋白水平升高有关，未受影响的半球比受影响的半球以及运动前皮层（PMC）和辅助运动区域的氧合血红蛋白水平更高。在第二次检查中，SMC激活的不对称性明显改善，患病半球的PMC激活增强。不对称SMC激活的改善与步态参数的改善显著相关。结论-卒中后运动恢复可能与受损半球SMC激活不对称性的改善和PMC激活的增强有关。
Background and Purpose - We sought to investigate cerebral mechanisms underlying locomotor recovery after stroke.Methods - We measured cortical activities during hemiparetic gait on the treadmill before and after 2 months of inpatient rehabilitation in 8 patients with initial stroke ( 5 men, 3 women; 4 with right and 4 with left hemiparesis; aged 57 years; 3 months after stroke on average), using an optical imaging system.Results - On the initial evaluation, hemiparetic gait was associated with increased oxygenated hemoglobin levels in the medial primary sensorimotor cortex ( SMC) that were greater in the unaffected hemisphere than in the affected hemisphere as well as in the premotor cortex ( PMC) and supplementary motor area. On the second examination, the asymmetry in SMC activation significantly improved, and there was enhanced PMC activation in the affected hemisphere. Improvement of the asymmetrical SMC activation significantly correlated with improvement of gait parameters.Conclusions - Locomotor recovery after stroke may be associated with improvement of asymmetry in SMC activation and enhanced PMC activation in the affected hemisphere.