Animal models in type 2 diabetes research: an overview.
Animal models in type 2 diabetes research: an overview.
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发表时间：
2007-03
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通讯作者：
K. Srinivasan;P. Ramarao
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作者：
K. Srinivasan;P. Ramarao
2型糖尿病是一种复杂的异质性疾病，目前影响着全世界1亿多人，并造成严重的社会经济问题。适当的实验模型是了解增加2型糖尿病风险的发病机制、并发症和遗传或环境影响以及测试各种治疗药物的重要工具。2型糖尿病的动物模型可以自发获得或通过化学品或饮食或手术操作和/或通过其组合诱导获得。近年来，大量新的转基因动物模型被用于糖尿病的研究，包括转基因小鼠、广义基因敲除小鼠和组织特异性基因敲除小鼠。本文就2型糖尿病动物模型的起源、特点、发病机制、优缺点等方面进行综述。此外，它特别描述了用于治疗2型糖尿病的各种新化学实体（NCE）的临床前试验中不同动物模型的适当选择和有用性。
Type 2 diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socio-economic problems. Appropriate experimental models are essential tools for understanding the pathogenesis, complications, and genetic or environmental influences that increase the risks of type 2 diabetes and testing of various therapeutic agents. The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations and/or by combination thereof. In recent years, large number of new genetically modified animal models including transgenic, generalized knock-out and tissue-specific knockout mice have been engineered for the study of diabetes. This review gives an overview on the animal models of type 2 diabetes with reference to their origin/source, characteristic features, underlying causes/mechanism(s), advantages and disadvantages to the investigators in diabetes research. In addition, it especially describes the appropriate selection and usefulness of different animal models in preclinical testing of various new chemical entities (NCEs) for the treatment of type 2 diabetes.