BioCichlid: central dogma-based 3D visualization system of time-course microarray data on a hierarchical biological network
BioCichlid: central dogma-based 3D visualization system of time-course microarray data on a hierarchical biological network
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DOI：
10.1093/bioinformatics/btp008
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发表时间：
2009-02-15
期刊：
影响因子：
5.8
通讯作者：
Tanaka, Hiroshi
中科院分区：
文献类型：
--
作者：
Ishiwata, Ryosuke R.;Morioka, Masaki S.;Tanaka, Hiroshi
BioCichlid是一个基于分子网络的时间进程微阵列数据的3D可视化系统，旨在通过基于物理和遗传相互作用的中心法则的转录关系来解释基因表达数据。BioCichlid可视化了物理（蛋白质）和遗传（调控）网络层，并在遗传网络层上提供了时间过程基因表达数据的动画。转录调控被表示为桥接物理网络（转录因子）和遗传网络（调节基因）层，从而将启动子分析整合到通路作图中。BioCichlid增强了微阵列数据的解释，并允许揭示导致差异基因表达的潜在机制。
BioCichlid is a 3D visualization system of time-course microarray data on molecular networks, aiming at interpretation of gene expression data by transcriptional relationships based on the central dogma with physical and genetic interactions. BioCichlid visualizes both physical (protein) and genetic (regulatory) network layers, and provides animation of time-course gene expression data on the genetic network layer. Transcriptional regulations are represented to bridge the physical network (transcription factors) and genetic network (regulated genes) layers, thus integrating promoter analysis into the pathway mapping. BioCichlid enhances the interpretation of microarray data and allows for revealing the underlying mechanisms causing differential gene expressions.