Total Synthesis of Echinomycin and Its Analogues
Total Synthesis of Echinomycin and Its Analogues
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DOI：
10.1021/acs.orglett.0c01268
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发表时间：
2020-06-05
期刊：
影响因子：
5.2
通讯作者：
Ichikawa, Satoshi
中科院分区：
文献类型：
--
作者：
Kojima, Keita;Yakushiji, Fumika;Ichikawa, Satoshi
棘霉素（1）的第一个全合成是通过Pummerer重排和同时环化的硫缩醛部分的后期构建以及肽链的双向延伸来实现的，以构建一个以硫键桥接的C2对称双环十八缩酚酸肽。该策略可适用于多种棘霉素类似物。
The first total synthesis of echinomycin (1) was accomplished by featuring the late-stage construction of the thioacetal moiety via Pummerer rearrangement and simultaneous cyclization, as well as two-directional elongation of the peptide chains to construct a C2-symmetrical bicyclic octadecadepsipeptide bridged with a sulfide linkage. This strategy can be applicable to a variety of echinomycin analogues.