The impact of isolated maternal hypothyroxinaemia on the incidence of large-for-gestational-age infants: the Ma'anshan Birth Cohort study
The impact of isolated maternal hypothyroxinaemia on the incidence of large-for-gestational-age infants: the Ma'anshan Birth Cohort study
复制标题
单纯产妇低甲状腺素血症对大于胎龄儿发生率的影响：马鞍山出生队列研究
DOI：
10.1111/1471-0528.15107
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发表时间：
2018-08-01
影响因子：
5.8
通讯作者：
Tao, F-b
中科院分区：
文献类型：
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作者：
Zhu, Y-d;Han, Y.;Tao, F-b
目的探讨单纯性母体甲状腺功能低下症(IMH)是否与小于胎龄儿/大胎龄儿(SGA/LGA)的发病风险有关。设计基于人群的前瞻性队列研究。设置中国马鞍山市妇幼保健所。人口统计方法对3178名单胎孕妇及其新生儿的人口学特征进行统计分析。采用线性回归方法估计甲状腺激素水平与出生体重之间的关系。采用Logistic回归分析计算IMH与SGA/LGA的关系。结果IMH的患病率早孕期为2.5%(78/3080)，中期为2.5%(74/2999)。SGA和LGA分别为306例(9.6%)和524例(16.5%)。没有证据支持IMH与妊娠期前[优势比(OR)：1.762，95%可信区间(CI)：0.759-4.089]或第二个孕期(OR：0.763，95%CI：0.231-2.516)的风险增加有关。然而，在妊娠中期观察到先天性巨噬细胞增多症的风险增加(OR：2.088，95%CI：1.193-3.654)。孕中期母体Tpo-Ab阳性增加了妊娠合并巨大儿的风险(OR：2.094，95%CI：1.333-3.290)。结论本研究提供了特发性甲减与巨大儿相关的证据。本研究得到中国国家自然科学基金资助(编号：81330068)。
ObjectiveThe purpose of this study was to investigate whether isolated maternal hypothyroxinaemia (IMH) is associated with risks of small/large-for-gestational-age (SGA/LGA) infants.DesignPopulation-based prospective cohort study.SettingMa'anshan Maternal and Child Health (MCH) clinics, China.PopulationPregnant women with singleton births (n = 3178).MethodsDescriptive statistics were calculated for the demographic characteristics of the mothers and their newborns. Linear regression was applied to estimate the association between thyroid hormone levels and birthweight. Logistic regression was performed to calculate the association between IMH and SGA/LGA.Main outcome measuresOutcomes included SGA/LGA.ResultsThe prevalence of IMH, defined as a free thyroxine value (FT4) lower than the 2.5th percentile with normal thyroid stimulating hormone, was 2.5% (78/3080) and 2.5% (74/2999) in the first and second trimesters, respectively. Additionally, 306 (9.6%) and 524 (16.5%) infants were defined as SGA and LGA, respectively. No evidence supported the notion that IMH is associated with an increased risk for SGA in either the first [odds ratio (OR): 1.762, 95% confidence interval (CI): 0.759-4.089] or the second (OR: 0.763, 95% CI: 0.231-2.516) trimester. However, an increased risk of LGA was observed among IMH women in the second trimester (OR: 2.088, 95% CI: 1.193-3.654). Maternal TPO-Ab positivity in the second trimester increased the risk of SGA (OR: 2.094, 95% CI: 1.333-3.290).ConclusionThis study provides evidence that IMH is associated with LGA.FundingThis work was supported by the National Natural Science Foundation of China (No. 81330068).Tweetable abstractIsolated maternal hypothyroxinaemia may increase the risk of large-for-gestational-age infants.Tweetable abstract Isolated maternal hypothyroxinaemia may increase the risk of large-for-gestational-age infants.