Feasibility of three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging as a prognostic factor in patients with sudden hearing loss
Feasibility of three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging as a prognostic factor in patients with sudden hearing loss
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DOI：
10.1007/s00405-011-1834-1
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发表时间：
2012-08-01
影响因子：
2.6
通讯作者：
Lee, Sun Kyu
中科院分区：
文献类型：
--
作者：
Lee, Ho Yun;Jung, Su Young;Lee, Sun Kyu
本研究的目的是证实三维液体衰减反转恢复磁共振成像（3D FLAIR MRI）高信号作为突发性特发性听力损失恢复的预后因素之一的可行性。对2008年1月至2010年12月诊断为单侧突发性听力损失的患者进行回顾性研究。共有120名患者参加了这项研究。3D FLAIR MRI造影前内耳高信号31例（25.8%；FHS），迷路增强89例（74.2%）。两组患者除最终听力外，其他特征无显著差异。FHS组最终纯酮平均值为49.4 dB，显著低于FNS组的36.7 dB （p = 0.037 < 0.05）。经多元回归分析，末听与初听、伴有头晕、听觉脑干异常反应结果相关。然而，在预对比3D FLAIR MRI上存在高强度信号对最终听力没有明显影响。全组与FHS组末听均因头晕而有显著性差异，FNS组末听无显著性差异。（p = 0.063 bb0 0.05）。从这些发现来看，3D FLAIR MRI上的高强度信号的存在是与头晕相关的一个亚因素，而不是单一的预后不良因素，3D FLAIR MRI上没有高强度信号可能意味着相对较好的预后。
The aim of this study was to confirm the feasibility of high signal on three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D FLAIR MRI) as one of the prognostic factors in recovery of sudden idiopathic hearing loss. A retrospective study was conducted using patients who were diagnosed with unilateral sudden idiopathic hearing loss from January 2008 to December 2010. A total of 120 patients were enrolled in for this study. High-intensity signal in the inner ear on precontrast 3D FLAIR MRI was observed in 31 patients (25.8%; FHS) and labyrinthine enhancement was not observed in another 89 patients (FNS; 74.2%). There was no significant difference in patients' characteristics between two groups except final hearing. Final puretone average of the FHS group was 49.4 dB, significantly worse than FNS group's 36.7 dB (p = 0.037 < 0.05). Final hearing was related to initial hearing, accompanying dizziness, and abnormal auditory brainstem response result by multiple regression analysis. However, presence of high-intensity signal on precontrast 3D FLAIR MRI did not affect final hearing significantly. Significant difference due to the presence of dizziness in final hearing was observed in whole patients and in the FHS group, whereas no significant difference in final hearing was observed in FNS group. (p = 0.063 > 0.05). From these findings, the presence of high-intensity signal on 3D FLAIR MRI is a subfactor related to dizziness rather than a single poor prognostic factor and the absence of high-intensity signal on 3D FLAIR MRI can possibly imply relative good prognosis.