Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication
Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication
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DOI：
10.1016/j.exger.2016.05.009
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发表时间：
2016-09-01
影响因子：
3.9
通讯作者：
Kjaer, M.
中科院分区：
文献类型：
--
作者：
Dideriksen, K.;Boesen, A. P.;Kjaer, M.
背景：非甾体抗炎药（NSAIDs）可能会增强阻力训练引起的骨骼肌质量和力量的增加，但目前尚不清楚NSAIDs是否会影响老年人不活动期间的肌肉损失。因此，我们研究了非甾体抗炎药治疗在固定和康复阻力训练（再训练）期间对人类骨骼肌的影响。方法：19名男性（60-80岁，范围）随机分配布洛芬（1200mg /d, Ibu）或安慰剂（Plc）。一只下肢用石膏固定2周，再训练6周。此外，在整个研究期间均摄入分离乳清蛋白（2 × 20 g/d）。研究了血浆炎症标志物、股四头肌肌肉质量和力量以及肌肉基因表达。结果：肌肉质量和力量在2周固定后下降（P < 0.001），但在2周再训练并补充乳清蛋白后恢复到基线水平（P < 0.001）。此外，再训练6周后，肌肉质量和力量超过基线水平（p < 0.05），非甾体抗炎药对这一点没有显著影响（p < 0.05）。肌肉中蛋白水解和合成代谢因子的基因表达没有组间差异，但随着时间的推移存在差异。血浆炎症标志物未受研究干预和非甾体抗炎药治疗的影响。结论：下肢固定两周导致肌肉量和力量减少，但在再训练和补充乳清蛋白两周后，这些参数已经恢复。再训练和补充乳清蛋白6周后，肌肉质量和力量超过基线水平，非甾体抗炎药治疗对老年人的影响不显著。(C) 2016 Elsevier Inc.版权所有。
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) may enhance resistance training induced gain in skeletal muscle mass and strength, but it is unknown if NSAIDs affects muscle loss during periods of inactivity in elderly individuals. Thus, we studied the influence of NSAID treatment on human skeletal muscle during immobilization and rehabilitation resistance training (retraining).Methods: 19 men (60-80 yrs, range) were randomly assigned to ibuprofen (1200 mg/d, Ibu) or placebo (Plc). One lower limb was immobilized in a cast for 2 weeks and retrained for 6 weeks. Moreover, whey protein isolate was ingested (2 x 20 g/d) throughout the whole study period. Plasma inflammatory markers, quadriceps muscle mass and strength, and muscle gene expression were investigated.Results: Muscle mass and strength decreased after 2 weeks of immobilization (P < 0.001), but returned to baseline levels after 2 weeks of retraining combined with whey protein supplementation (P < 0.001). Furthermore, muscle mass and strength reached beyond baseline levels after 6 weeks of retraining (p < 0.05), and NSAID did not significantly affect this (p > 0.05). No group-differences, but differences over time, were observed for muscle gene expression of proteolytic and anabolic factors. Plasma inflammatory markers were unaffected by the study intervention and NSAID treatment.Conclusion: Two weeks of lower limb immobilization lead to a reduction in muscle mass and strength, but these parameters were restored already after 2 weeks of retraining and whey protein supplementation. After 6 weeks of retraining and whey protein supplementation, muscle mass and strength increased beyond baseline levels, and NSAID treatment did not significantly influence this in elderly. (C) 2016 Elsevier Inc. All rights reserved.