Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing-remitting multiple sclerosis
Quantitative diffusion tensor deterministic and probabilistic fiber tractography in relapsing-remitting multiple sclerosis
复制标题
复发缓解型多发性硬化症的定量扩散张量确定性和概率纤维束成像
DOI：
10.1016/j.ejrad.2009.11.021
复制
发表时间：
2011-07-01
影响因子：
3.3
通讯作者：
Shan, Hong
中科院分区：
文献类型：
--
作者：
Hu, Bing;Ye, Binbin;Shan, Hong
目的：本研究的目的是研究定量纤维束成像在复发缓解型多发性硬化（RRMS）患者中的变化和模式，并评估定量纤维束成像与扩展残疾状态量表（EDSS）之间的相关性。材料和方法：28例RRMS患者和28例年龄匹配的健康志愿者进行了弥散张量MR成像研究。定量确定性和概率纤维束成像在所有科目中产生。并计算平均追踪线数和纤维密度。配对样本t检验用于比较RRMS患者与对照组的追踪线和纤维密度。结果：RRMS患者确定性和概率性纤维束成像的追踪线数和纤维密度均低于对照组（P
Purpose: Our aim was to study the quantitative fiber tractography variations and patterns in patients with relapsing-remitting multiple sclerosis (RRMS) and to assess the correlation between quantitative fiber tractography and Expanded Disability Status Scale (EDSS).Material and methods: Twenty-eight patients with RRMS and 28 age-matched healthy volunteers underwent a diffusion tensor MR imaging study. Quantitative deterministic and probabilistic fiber tractography were generated in all subjects. And mean numbers of tracked lines and fiber density were counted. Paired-samples t tests were used to compare tracked lines and fiber density in RRMS patients with those in controls. Bivariate linear regression model was used to determine the relationship between quantitative fiber tractography and EDSS in RRMS.Results: Both deterministic and probabilistic tractography's tracked lines and fiber density in RRMS patients were less than those in controls (P