Ventral Premotor and Inferior Parietal Cortices Make Distinct Contribution to Action Organization and Intention Understanding
Ventral Premotor and Inferior Parietal Cortices Make Distinct Contribution to Action Organization and Intention Understanding
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DOI：
10.1093/cercor/bhp200
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发表时间：
2010-06-01
期刊：
影响因子：
3.7
通讯作者：
Fogassi, Leonardo
中科院分区：
文献类型：
--
作者：
Bonini, Luca;Rozzi, Stefano;Fogassi, Leonardo
腹侧运动前区F5负责编码被执行和被观察到的运动动作的目标。这个区域在解剖学上与下顶叶皮层（PFG区）的一部分相连，最近已被证明在行动组织和意图理解中发挥作用。本研究的目的是：1）评估F5运动神经元和镜像神经元（MN）的放电是否编码动作目标; 2）阐明F5和PFG在动作组织和意图理解中的相对贡献。为了这个目的，我们首先记录了从F5运动神经元和MN的2只猴子，同时执行由2个动作（“抓吃”和“抓地方”）或观察相同的任务由实验者完成的运动任务。结果表明，一些F5神经元编码抓取根据其嵌入的动作的目标。随后，我们记录了PFG运动神经元和MN的相同的猴子，使用相同的任务。F5和PFG运动神经元的神经元特性之间的比较表明，PFG在组织自然行为中起着重要作用。此外，这两个区域的MNs特性之间的相似性表明它们构成了他人意图理解的功能回路。
It is well known that ventral premotor area F5 codes the goal of executed and observed motor acts. This area is anatomically connected with part of the inferior parietal cortex (area PFG), which has been recently shown to play a role in action organization and intention understanding. The aims of the present study were 1) to assess whether the discharge of F5 motor neurons and mirror neurons (MNs) codes action goals and 2) to clarify the relative contribution of F5 and PFG in action organization and intention understanding. To this purpose, we first recorded from F5 motor neurons and MNs of 2 monkeys while performing a motor task constituted by 2 actions ("grasp-to-eat" and "grasp-to-place") or observing the same task done by an experimenter. Results showed that some F5 neurons code grasping according to the goal of the action in which it is embedded. Subsequently, we recorded from PFG motor neurons and MNs of the same monkeys, using the same tasks. The comparison between the neuronal properties of F5 and PFG motor neurons suggests that PFG plays a major role in organizing natural actions. Furthermore, the similarities between MNs properties of the 2 areas indicate that they constitute a functional circuit underlying others' intention understanding.