Review Article Rickets, Osteomalacia, and Renal Osteodystrophy
Review Article Rickets, Osteomalacia, and Renal Osteodystrophy
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评论文章佝偻病、骨软化症和肾性骨营养不良
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
H. Mankin
中科院分区：
文献类型：
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作者：
H. Mankin
佝偻病和骨软化症可能是由于广泛的遗传性和获得性代谢异常引起的，这些代谢异常引起血清钙、磷酸盐或两者的充分降低，从而损害骨骼的矿化和骨骺生长。虽然这些不同的异常可能会导致惊人的相似的结果在受影响的患者，各自的疾病通常可以分开，并通过仔细评估的临床，X线和实验室数据确定。预后和治疗可能会有很大的不同，这取决于佝偻病或骨软化症的原因。必须仔细研究每个患者，并针对其特定的代谢异常采用适当的方案进行治疗。
Rickets and osteomalacia may result from a wide spectrum of inherited and acquired metabolic abnormalities which produce sufficient decrease in serum calcium, phosphate, or both to impair mineralization of the skeleton and epiphyseal growth. Although these various abnormalities may cause strikingly similar findings in affected patients, the respective diseases can usually be separated and identified by careful evaluation of the clinical, roentgenographic, and laboratory data. The prognosis and treatment may vary considerably depending on the cause of the rickets or osteomalacia. Each patient must be carefully studied and treated with the appropriate regimen for his or her particular metabolic abnormality.