First inductively coupled plasma-distance-of-flight mass spectrometer: instrument performance with a microchannel plate/phosphor imaging detector
First inductively coupled plasma-distance-of-flight mass spectrometer: instrument performance with a microchannel plate/phosphor imaging detector
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DOI：
10.1039/c3ja50122a
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发表时间：
2013-08
影响因子：
3.4
通讯作者：
Alexander Gundlach-Graham;Elise A. Dennis;S. Ray;C. Enke;C. Barinaga;D. Koppenaal;G. Hieftje
中科院分区：
文献类型：
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作者：
Alexander Gundlach-Graham;Elise A. Dennis;S. Ray;C. Enke;C. Barinaga;D. Koppenaal;G. Hieftje
在这里，我们描述了第一个飞行距离质谱（DOFMS）仪器和电感耦合等离子体（ICP）离子源的组合。DOFMS是一种基于速度的MS技术，其中沿空间选择性检测器的长度沿着同时检测质荷比（m/z）值范围的离子。作为飞行时间（TOF）MS的相对物，DOFMS利用了TOFMS和空间分散MS两者的益处。m/z值组的同时检测通过将离子信号散布在许多检测器元件上来提高动态范围，并且通过信号比率来降低相关噪声。为了确定ICP-DOFMS仪器的性能特性，我们采用了微通道板/荧光检测组件与科学CCD捕获荧光板的图像。通过这种简单的（商业上可获得的）检测方案，元素检测限为2-30 ng L-1，线性动态范围为5个数量级（10-106 ng L-1）。此外，具有竞争力的同位素比精度为0.1%的RSD已经实现了只有6秒的信号积分周期。除了第一品质因数，本文概述了设计的ICP-DOFMS的技术考虑。
Here we describe the first combination of a Distance-of-Flight Mass Spectrometry (DOFMS) instrument and an inductively coupled plasma (ICP) ion source. DOFMS is a velocity-based MS technique in which ions of a range of mass-to-charge (m/z) values are detected simultaneously along the length of a spatially selective detector. As a relative of time-of-flight (TOF) MS, DOFMS leverages benefits from both TOFMS and spatially dispersive MS. The simultaneous detection of groups of m/z values improves dynamic range by spreading ion signal across many detector elements and reduces correlated noise by signal ratioing. To ascertain the performance characteristics of the ICP-DOFMS instrument, we have employed a microchannel-plate/phosphor detection assembly with a scientific CCD to capture images of the phosphor plate. With this simple (and commercially available) detection scheme, elemental detection limits from 2–30 ng L−1 and a linear dynamic range of 5 orders of magnitude (10–106 ng L−1) have been demonstrated. Additionally, a competitive isotope-ratio precision of 0.1% RSD has been achieved with only a 6 s signal integration period. In addition to first figures of merit, this paper outlines technical considerations for the design of the ICP-DOFMS.