Early lymphocyte recovery predicts longer survival after autologous peripheral blood stem cell transplantation in multiple myeloma
Early lymphocyte recovery predicts longer survival after autologous peripheral blood stem cell transplantation in multiple myeloma
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DOI：
10.1038/sj.bmt.1705373
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发表时间：
2006-06-01
影响因子：
4.8
通讯作者：
Suh, C.
中科院分区：
文献类型：
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作者：
Kim, H.;Sohn, H-J;Suh, C.
为了解自体外周血干细胞移植(APBSCT)后淋巴细胞恢复的预后价值，我们对59例新诊断的多发性骨髓瘤(MM)患者进行了一线APBSCT的回顾性研究。预适应方案为马法兰100 mg/m(2)，连用2天。APBSCT后，所有患者均表现为完全或部分缓解。中位随访时间为29.57个月，淋巴细胞绝对计数(ALC)和绝对淋巴细胞计数(GT；)=1000/mm(3)的中位恢复时间为23天。单因素分析显示，总生存期(OS)的显著预测因素包括骨髓浆细胞数=1,000/mm(3)/天+23天(P=0.0156)。无进展生存期(PFS)的阳性预测因素为骨髓浆细胞数=1,000/mm~3/天(P+0.0243)。+12天中性粒细胞绝对数=1,000/mm~3对OS和PFS有轻微意义(分别为P=0.0821和P=0.1153)。多因素分析显示+23天ALC和gt；=1,000/mm(3)独立预测OS(P=0.031)和PFS延长(P=0.011)，血清β2-微球蛋白对OS延长无显著意义(P=0.066)。综上所述，ALC恢复是MM患者OS和PFS的独立预测因子。
To understand the prognostic value of lymphocyte recovery after autologous peripheral blood stem cell transplantation (APBSCT), we performed a retrospective study of 59 newly diagnosed multiple myeloma (MM) patients who underwent frontline APBSCT. Conditioning regimens were melphalan 100 mg/m(2) for 2 days. Following APBSCT, all patients showed complete or partial response. Median follow-up time was 29.57 months and median recovery of absolute lymphocyte count (ALC) >= 1000/mm(3) was 23 days. Univariate analysis revealed that significant predictors of overall survival (OS) included bone marrow (BM) plasma cells = 1000/mm(3) by day +23 (P = 0.0156). Positive predictors for progression-free survival (PFS) were BM plasma cells = 1000/mm3 by day +23 (P + 0.0243). Absolute neutrophil count >= 1000/mm3 on day +12 was marginally significant for OS and PFS (P = 0.0821 and P = 0.1153, respectively). Multivariate analysis showed that ALC >= 1000/mm(3) on day +23 independently predicted OS (P = 0.031) and prolonged PFS (P = 0.011), and that serum beta 2-microglobulin was marginally significant for prolonged OS (P = 0.066). In conclusion, ALC recovery was an independent predictor of both OS and PFS in MM.