Subverting Toll-Like Receptor Signaling by Bacterial Pathogens.
Subverting Toll-Like Receptor Signaling by Bacterial Pathogens.
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DOI：
10.3389/fimmu.2015.00607
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发表时间：
2015
影响因子：
7.3
通讯作者：
Arthur JS
中科院分区：
文献类型：
--
作者：
McGuire VA;Arthur JS
致病菌是通过先天免疫细胞上表达的模式识别受体（PRRs）检测到的，它激活细胞内信号转导途径，引发免疫反应。toll样受体可能是研究最多的PRRs，可以激活丝裂原活化蛋白激酶（MAPK）和核因子-κB （NF-κB）途径。这些途径对于建立有效的免疫反应至关重要。为了逃避检测和增强毒力，许多病原体通过靶向这些信号转导途径的成分来破坏宿主的免疫反应。这篇迷你综述强调了细菌病原体进化来操纵先天免疫反应的多种机制，特别关注那些针对MAPK和NF-κB信号通路的机制。了解病原体用来破坏免疫反应的复杂策略不仅突出了这些蛋白质在建立有效免疫反应中的重要性，而且还可能确定治疗或预防感染的新方法。
Pathogenic bacteria are detected by pattern-recognition receptors (PRRs) expressed on innate immune cells, which activate intracellular signal transduction pathways to elicit an immune response. Toll-like receptors are, perhaps, the most studied of the PRRs and can activate the mitogen-activated protein kinase (MAPK) and Nuclear Factor-κB (NF-κB) pathways. These pathways are critical for mounting an effective immune response. In order to evade detection and promote virulence, many pathogens subvert the host immune response by targeting components of these signal transduction pathways. This mini-review highlights the diverse mechanisms that bacterial pathogens have evolved to manipulate the innate immune response, with a particular focus on those that target MAPK and NF-κB signaling pathways. Understanding the elaborate strategies that pathogens employ to subvert the immune response not only highlights the importance of these proteins in mounting effective immune responses, but may also identify novel approaches for treatment or prevention of infection.