Fluid, electrolyte, and renal indices of hydration during 11 days of controlled caffeine consumption
Fluid, electrolyte, and renal indices of hydration during 11 days of controlled caffeine consumption
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DOI：
10.1123/ijsnem.15.3.252
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发表时间：
2005-06-01
影响因子：
2.5
通讯作者：
Kellogg, M
中科院分区：
文献类型：
--
作者：
Armstrong, LE;Pumerantz, AC;Kellogg, M
本研究旨在确定3种不同水平的咖啡因受控摄入量是否对体液 - 电解质平衡和肾功能产生不同影响。健康男性（平均标准差；年龄，21.6±3.3岁）在第1天至第6天（平衡期）摄入3毫克·千克⁻¹·天⁻¹的咖啡因。在第7天至第11天（治疗期），受试者分别摄入0毫克（C0；安慰剂；n = 20）、3毫克（C3；n = 20）或6毫克（C6；n = 19）·千克⁻¹·天⁻¹的咖啡因胶囊，且无其他饮食咖啡因摄入。在第1、3、6、9和11天，以下变量不受不同咖啡因剂量的影响（P>0.05），且均在正常临床范围内：体重、尿渗透压、尿比重、尿色、24小时尿量、24小时钠⁺和钾⁺排泄量、24小时肌酐、血尿素氮、血清钠⁺和钾⁺、血清渗透压、血细胞比容和血浆总蛋白。因此，C0、C3和C6均未显示出脱水的迹象。这些发现对广泛接受的咖啡因摄入长期作为利尿剂的观点提出了质疑。
This investigation determined if 3 levels of controlled caffeine consumption affected fluid-electrolyte balance and renal function differently. Healthy males (mean standard deviation; age, 21.6 +/- 3.3 y) consumed 3 mg caffeine (.) kg(-1) (.) d(-1) on days I to 6 (equilibration phase). On days 7 to 11 (treatment phase), subjects consumed either 0 mg (CO; placebo; n = 20), 3 mg (C3; n = 20), or 6 mg (C6; n = 19) caffeine (.) kg(-1) (.) d(-1) in capsules, with no other dietary caffeine intake. The following variables were unaffected (P > 0.05) by different caffeine doses on days 1, 3, 6, 9, and 11 and were within normal clinical ranges: body mass, urine osmolality, urine specific gravity, urine color, 24-h urine volume, 24-h Na+ and K+ excretion, 24-h creatinine, blood urea nitrogen, serum Na+ and K+, serum osmolality, hematocrit, and total plasma protein. Therefore, C0, C3, and C6 exhibited no evidence of hypohydration. These findings question the widely accepted notion that caffeine consumption acts chronically as a diuretic.