MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction.
MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction.
复制标题
DOI：
10.1016/j.biomaterials.2015.08.011
复制
发表时间：
2015-11
期刊：
影响因子：
14
通讯作者：
Burdick JA
中科院分区：
文献类型：
--
作者：
Dorsey SM;McGarvey JR;Wang H;Nikou A;Arama L;Koomalsingh KJ;Kondo N;Gorman JH 3rd;Pilla JJ;Gorman RC;Wenk JF;Burdick JA
可注射生物材料是一种有吸引力的治疗方法，以减轻心肌梗死（MI）后左心室（LV）重塑。尽管研究表明可注射水凝胶可改善体内心脏结构和功能，但尚未评估治疗后梗死材料性质的时间变化。新兴的成像和建模技术现在允许连续的，非侵入性的估计梗死材料的属性。具体而言，电影MRI评估整体LV结构和功能，晚期钆增强（LGE）MRI能够可视化梗死组织以量化梗死扩展，磁化空间调制（SPAMM）标记提供被动室壁运动评估作为组织应变的测量，当与有限元（FE）模型结合时，这些都可以用于评估梗死特性。在这项工作中，我们研究了可降解的透明质酸（HA）水凝胶对全球左心室重构，梗死变薄和扩大，和梗死刚度在猪梗死模型MI后12周的MRI和FE建模的时间效应。与对照组相比，水凝胶治疗导致LV容积减少，射血分数改善，室壁厚度增加。FE模型模拟表明，水凝胶治疗增加了MI后12周的梗死刚度。因此，通过MRI和FE建模评价心肌组织特性，可深入了解可注射水凝胶疗法对MI后心肌结构和功能的影响。
Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling after myocardial infarction (MI). Although studies have shown that injectable hydrogels improve cardiac structure and function in vivo, temporal changes in infarct material properties after treatment have not been assessed. Emerging imaging and modeling techniques now allow for serial, non-invasive estimation of infarct material properties. Specifically, cine MRI assesses global LV structure and function, late-gadolinium enhancement (LGE) MRI enables visualization of infarcted tissue to quantify infarct expansion, and spatial modulation of magnetization (SPAMM) tagging provides passive wall motion assessment as a measure of tissue strain, which can all be used to evaluate infarct properties when combined with finite element (FE) models. In this work, we investigated the temporal effects of degradable hyaluronic acid (HA) hydrogels on global LV remodeling, infarct thinning and expansion, and infarct stiffness in a porcine infarct model for 12 weeks post-MI using MRI and FE modeling. Hydrogel treatment led to decreased LV volumes, improved ejection fraction, and increased wall thickness when compared to controls. FE model simulations demonstrated that hydrogel therapy increased infarct stiffness for 12 weeks post-MI. Thus, evaluation of myocardial tissue properties through MRI and FE modeling provides insight into the influence of injectable hydrogel therapies on myocardial structure and function post-MI.