Estimation of radiation dose to patients from (18) FDG whole body PET/CT investigations using dynamic PET scan protocol.
Estimation of radiation dose to patients from (18) FDG whole body PET/CT investigations using dynamic PET scan protocol.
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DOI：
10.4103/0971-5916.174563
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Dwarakanath BS
中科院分区：
文献类型：
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作者：
Kaushik A;Jaimini A;Tripathi M;D'Souza M;Sharma R;Mondal A;Mishra AK;Dwarakanath BS
人们越来越关注接受 18FDG PET/CT（18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描）全身检查的患者的辐射暴露。本研究的目的是研究 18FDG 分布的动力学并估计接受 18FDG 全身 PET/CT 检查的患者所接受的辐射剂量。对49例患者进行了身体不同部位的动态PET扫描，以测量脑、肝、脾、肾上腺、肾和胃中18FDG的摄取百分比。使用 OLINDA 软件计算这些器官中的停留时间并估算辐射剂量。 CT 组件的辐射剂量使用 CT-Expo 软件进行计算，并使用计算机断层扫描剂量指数 (CTDI) 体模和电离室进行测量。根据临床方案，患者在研究前至少 4 小时内禁食和饮水。男性的估计停留时间为 0.196 小时（大脑）、0.09 小时（肝脏）、0.007 小时（脾脏）、0.0006 小时（肾上腺）、0.013 小时（肾脏）和 0.005 小时（胃），而男性的估计停留时间为 0.189 小时（大脑）、0.11 小时（肝脏）、0.01 小时（脾脏）、0.0007 小时（肾上腺）、0.02 小时（肾脏）和 女性 0.004 小时（胃）。发现内部施用 18FDG 的有效剂量为男性 0.020 mSv/MBq，女性为 0.025 mSv/MBq，CT 成分的男性有效剂量为 6.8 mSv，女性为 7.9 mSv。对于 18FDG 的施用活性为 370 MBq，PET/CT 检查的有效剂量估计男性为 14.2 mSv，女性为 17.2 mSv。目前的结果并未表明男性和女性患者中 18FDG 分布动力学存在显着差异。估计的 PET/CT 剂量被发现高于许多其他常规诊断放射学检查，这表明在每次 18FDG 全身 PET/CT 扫描之前应尽一切努力在临床上证明合理性并仔细权衡风险效益比。
There is a growing concern over the radiation exposure of patients from undergoing 18FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography/computed tomography) whole body investigations. The aim of the present study was to study the kinetics of 18FDG distributions and estimate the radiation dose received by patients undergoing 18FDG whole body PET/CT investigations. Dynamic PET scans in different regions of the body were performed in 49 patients so as to measure percentage uptake of 18FDG in brain, liver, spleen, adrenals, kidneys and stomach. The residence time in these organs was calculated and radiation dose was estimated using OLINDA software. The radiation dose from the CT component was computed using the software CT-Expo and measured using computed tomography dose index (CTDI) phantom and ionization chamber. As per the clinical protocol, the patients were refrained from eating and drinking for a minimum period of 4 h prior to the study. The estimated residence time in males was 0.196 h (brain), 0.09 h (liver), 0.007 h (spleen), 0.0006 h (adrenals), 0.013 h (kidneys) and 0.005 h (stomach) whereas it was 0.189 h (brain), 0.11 h (liver), 0.01 h (spleen), 0.0007 h (adrenals), 0.02 h (kidneys) and 0.004 h (stomach) in females. The effective dose was found to be 0.020 mSv/MBq in males and 0.025 mSv/MBq in females from internally administered 18FDG and 6.8 mSv in males and 7.9 mSv in females from the CT component. For an administered activity of 370 MBq of 18FDG, the effective dose from PET/CT investigations was estimated to be 14.2 mSv in males and 17.2 mSv in females. The present results did not demonstrate significant difference in the kinetics of 18FDG distribution in male and female patients. The estimated PET/CT doses were found to be higher than many other conventional diagnostic radiology examinations suggesting that all efforts should be made to clinically justify and carefully weigh the risk-benefit ratios prior to every 18FDG whole body PET/CT scan.