WAVELENGTH DEPENDENCY OF CATARACTS IN ALBINO MICE FOLLOWING CHRONIC EXPOSURE
WAVELENGTH DEPENDENCY OF CATARACTS IN ALBINO MICE FOLLOWING CHRONIC EXPOSURE
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DOI：
10.1016/s0014-4835(85)80011-7
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发表时间：
1985-01-01
影响因子：
3.4
通讯作者：
PITTS, DG
中科院分区：
文献类型：
--
作者：
JOSE, JG;PITTS, DG
白化小鼠染毒1次。紫外线照射范围为290~400 nm，每天照射12小时，照射剂量为10-4W·cm~(-2)，照射后1~2个月内出现晶状体前混浊。组织学改变显示晶状体上皮细胞明显排列紊乱。当用玻璃过滤辐射，排除短于320 nm的辐射时，这些混浊不会形成，晶状体的组织学是正常的。我们得出结论，在慢性暴露后，UV-B(290-320 nm)辐射是导致白内障的，并通过涉及晶状体上皮的机制起作用。UV-A(320-400纳米)似乎不会导致白内障，即使是在长期暴露的情况下。
Albino mice exposed to 1 .times. 10-4 W cm-2 of UV radiation in the range 290-400 nm for 12 hr per day developed anterior lens opacities within 1-2 months after onset of the exposure. Histological changes demonstrated marked derangement of the lens epithelium. When the radiation was filtered with glass, eliminating radiation shorter than 320 nm, these opacities did not develop and the histology of the lenses was normal. We conclude that following chronic exposure UV-B (290-320 nm) radiation is cataractogenic and acts via a mechanism involving the lens epithelium. UV-A (320-400 nm) does not appear to be cataractogenic, even with chronic exposure.