The Association Between TP53 Arg72Pro Polymorphism and Lung Cancer Susceptibility: Evidence from 30,038 Subjects
The Association Between TP53 Arg72Pro Polymorphism and Lung Cancer Susceptibility: Evidence from 30,038 Subjects
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TP53 Arg72Pro 多态性与肺癌易感性之间的关联：来自 30,038 名受试者的证据
DOI：
10.1007/s00408-013-9461-9
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发表时间：
2013-08-01
期刊：
影响因子：
5
通讯作者：
Hu, Weiguo
中科院分区：
文献类型：
--
作者：
Qiao, Qian;Hu, Weiguo
TP53密码子72多态与个体肺癌易感性有关。然而，这种关联仍然不确定，而且随着种族、吸烟状况、癌症组织学和分期的不同而不同。我们基于36篇已发表文献中的15,647名肺癌患者和14,391名对照，进行了一项荟萃分析，以评估TP53 Arg72Pro基因多态与肺癌易感性的关系。我们还对不同种族、吸烟状况、肺癌分期和组织类型的人群进行了分层分析。分析显示，Pro等位基因携带者显著增加了肺癌的易感性(P<；0.001，优势比(OR)=1.14，95%可信区间(CI)=1.1-1.19)，尤其是吸烟者(P<；0.001，OR=1.29，95%CI=1.12-1.47)。分层分析表明，Pro72在亚洲人中增加了肺癌的易感性，而对高加索人的肺癌风险没有影响。此外，Pro携带者患鳞状细胞癌和腺癌的风险比大细胞癌和小细胞癌高。有趣的是，携带Pro等位基因的患者似乎在早期就被诊断为肺癌(I-II期，P=0.008，OR=1.2，95%CI=1.0-1.37)。我们的结果表明，Pro等位基因是肺癌发生的危险因素，尤其是对吸烟者和亚洲人。
The TP53 codon 72 polymorphism has been associated with the individual susceptibility to lung cancer. However, the association remains uncertain and varies with ethnicity, smoking status, cancer histology, and stage.We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures. We also performed stratified analysis in populations of different ethnicities, smoking statuses, lung cancer stages, and histological types.The analysis showed a significantly increased lung cancer susceptibility among Pro allele carriers (P < 0.001, odds ratio (OR) = 1.14, 95 % confidence interval (CI) = 1.1-1.19), especially for smokers (P < 0.001, OR = 1.29, 95 % CI = 1.12-1.47). Stratified analysis indicated that Pro72 elevates lung cancer susceptibility in Asians, while it has no effect on lung cancer risk of Caucasians. Moreover, Pro carriers present an increased risk of developing squamous cell carcinoma and adenocarcinoma, instead of large cell carcinoma and small cell carcinoma. Interestingly, patients with the Pro allele seemed to be diagnosed with lung cancer at the early stages (stage I-II, P = 0.008, OR = 1.2, 95 % CI = 1.05-1.37).Our results suggest that the Pro allele acts as a risk factor for development of lung cancer, especially for smokers and Asians.