Early hits and long-term consequences: tracking the lasting impact of prenatal smoke exposure on telomere length in children.
Early hits and long-term consequences: tracking the lasting impact of prenatal smoke exposure on telomere length in children.
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DOI：
10.2105/ajph.2012.301208
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发表时间：
2013-09
影响因子：
12.7
通讯作者：
K. Theall;S. McKasson;Emily Mabile;L. F. Dunaway;S. Drury
中科院分区：
文献类型：
--
作者：
K. Theall;S. McKasson;Emily Mabile;L. F. Dunaway;S. Drury
We examined the association between telomere length and prenatal tobacco exposure (PTE) in 104 children aged 4 to 14 years. Salivary telomere length (STL) was determined from salivary DNA using quantitative polymerase chain reaction. Of the children, 18% had maternal reported PTE. Mean STL was significantly lower among children with PTE (6.4 vs 7.5, P < .05). Findings extend the literature demonstrating the negative long-term effects of PTE to include a cellular marker of aging linked to multiple negative health outcomes.
