AGING AND DEGENERATION OF THE HUMAN MACULA .1. OUTER NUCLEAR LAYER AND PHOTORECEPTORS
AGING AND DEGENERATION OF THE HUMAN MACULA .1. OUTER NUCLEAR LAYER AND PHOTORECEPTORS
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DOI：
10.1136/bjo.65.1.23
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发表时间：
1981-01-01
影响因子：
4.1
通讯作者：
HENKIND, P
中科院分区：
文献类型：
--
作者：
GARTNER, S;HENKIND, P
本文对104例3-96岁病人的黄斑进行了光镜检查。从外核层到外丛状层的细胞核移位发生在生命早期的少数，并在30岁后显着增加。在生命早期，细胞核从外核层转移到视杆细胞层和视锥细胞层的现象很少，但在40岁以后这种现象大大增加。核的位移可能是继发于其附着的纤维的收缩，并与老化。移位的细胞核在大小、形状和染色质含量上明显发生变化，并可能继续坏死。104只眼中有24只眼外核层细胞核数目及黄斑区光感受器数目明显减少。所有患者均为40岁以上的患者。未发现下颌色素上皮、Bruch膜或脉络膜毛细血管的伴随缺陷。外核层细胞核的丢失似乎是与衰老相关的原发性视网膜疾病。
The macula of 104 human eyes obtained at necropsy of patients 3-96 yr old were examined by light microscopy. Displacement of nuclei from the outer nuclear layer into the outer plexiform layer occurred in small numbers early in life and markedly increased after age 30. Displacement of nuclei from the outer nuclear layer to the layer of rods and cones was rare in early life but increased considerably after age 40. Displacement of nuclei was probably secondary to shrinkage of their attached fibers and associated with aging. Displaced nuclei apparently undergo changes in size, shape and chromatin content and may go on to necrosis. Of the 104 eyes, 24 had an obvious reduction in the numbers of nuclei in the outer nuclear layer and their photoreceptors in the macular zone. All were in eyes from patients over age 40. No concomitant defect was found in the subjacent pigment epithelium, Bruch''s membrane or choriocapillaris. The loss of nuclei of the outer nuclear layer appears a primary retinal disorder associated with aging.