Spin trapping of 13C-labeled p-benzynes generated by Masamune-Bergman cyclization of bicyclic nine-membered enediynes.
Spin trapping of 13C-labeled p-benzynes generated by Masamune-Bergman cyclization of bicyclic nine-membered enediynes.
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双环九元烯二炔的 Masamune-Bergman 环化产生的 13C 标记的对苯炔的自旋捕获。
DOI：
10.1002/anie.200454133
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发表时间：
2004
影响因子：
--
通讯作者：
S. Tero
中科院分区：
文献类型：
--
作者：
Toyonobu Usuki;Takashi Mita;M. J. Lear;Parthasarathi Das;Fumihiko Yoshimura;M. Inoue;M. Hirama*;K. Akiyama;S. Tero
我们对烯二炔类抗肿瘤抗生素的化学和生物学的理解仍在发展中，
面临进一步的挑战。烯二炔衍生的双链DNA通过夺氢切割
自由基是一种普遍接受的机制。然而，几个意想不到的和复杂的机制，
烯二炔的细胞毒性作用，如RNA和蛋白质损伤或对苯醌类物质的产生，尚未完全阐明。尽管对简化系统进行了一些精心设计的实验和理论研究，
这种细胞毒性的主要化学肇事者，即由天然烯二炔形成的双自由基中间体的行为，与其说是事实，不如说是一种推测。
Our understanding of the chemistry and biology of the enediyne class of antitumor antibiotics is still developing and
faces further challenges. The cleavage of double-stranded DNA through hydrogen abstraction by enediyne-derived
radicals is a generally well-accepted mechanism. However, the mechanisms of several unexpected and complex
cytotoxic effects of enediynes,such as RNA and protein damage or the generation of p-quinone species, have yet to be fully elucidated. Despite several carefully crafted experimental and theoretical studies on simplified systems,the
behavior of the major chemical perpetrators of such cytotoxicity, namely the biradical intermediates formed by natural enediynes, remains more a matter of conjecture than a point of fact.