Central Inhibition of Tumor Necrosis Factor Alpha Reduces Hypertension by Attenuating Oxidative Stress in the Rostral Ventrolateral Medulla in Renovascular Hypertensive Rats
Central Inhibition of Tumor Necrosis Factor Alpha Reduces Hypertension by Attenuating Oxidative Stress in the Rostral Ventrolateral Medulla in Renovascular Hypertensive Rats
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DOI：
10.3389/fphys.2019.00491
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发表时间：
2019-04-30
影响因子：
4
通讯作者：
Braga, Valdir A.
中科院分区：
文献类型：
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作者：
Carvalho-Galvao, Alynne;Guimaraes, Drielle D.;Braga, Valdir A.
中枢神经系统的炎症被认为是与神经源性高血压有关的关键因素。采用体内和体外联合方法，我们研究了中枢性抑制tnf - α对2肾-1夹（2K1C）肾血管性高血压大鼠的血压、交感神经张力、压力反射敏感性和氧化应激的影响。肾血管性高血压大鼠连续14天向脑侧脑室输注tnf - α抑制剂己酮茶碱，可降低血压，改善压力反射敏感性。此外，中枢tnf - α抑制降低了交感调节，减弱了2K1C大鼠RVLM中增加的超氧化物积累。我们的研究结果表明，在肾血管性高血压期间，tnf - α在维持交感血管舒张性张力和RVLM氧化应激增加中起重要作用。
Inflammation in the central nervous system is being considered a key player linked to neurogenic hypertension. Using combined in vivo and in vitro approaches, we investigated the effects of central inhibition of TNF-alpha on blood pressure, sympathetic tone, baroreflex sensitivity, and oxidative stress in the rostral ventrolateral medulla (RVLM) of rats with 2-kidney-1-clip (2K1C) renovascular hypertension. Continuous infusion of pentoxifylline, a TNF-alpha inhibitor, into the lateral ventricle of the brain for 14 consecutive days reduced blood pressure and improved baroreflex sensitivity in renovascular hypertensive rats. Furthermore, central TNF-alpha inhibition reduced sympathetic modulation and blunted the increased superoxide accumulation in the RVLM of 2K1C rats. Our findings suggest that TNF-alpha play an important role in the maintenance of sympathetic vasomotor tone and increased oxidative stress in the RVLM during renovascular hypertension.