ASSOCIATION OF SOS RAS EXCHANGE PROTEIN WITH GRB2 IS IMPLICATED IN TYROSINE KINASE SIGNAL TRANSDUCTION AND TRANSFORMATION
ASSOCIATION OF SOS RAS EXCHANGE PROTEIN WITH GRB2 IS IMPLICATED IN TYROSINE KINASE SIGNAL TRANSDUCTION AND TRANSFORMATION
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DOI：
10.1038/363045a0
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发表时间：
1993-05-06
期刊：
影响因子：
64.8
通讯作者：
WEINBERG, RA
中科院分区：
文献类型：
--
作者：
EGAN, SE;GIDDINGS, BW;WEINBERG, RA
Grb2-Sem-5、Shc和SOS蛋白参与了酪氨酸激酶受体到RAS的信号转导通路。Grb2-Sem-5通过两个SH3结构域与RAS交换因子Sos1直接结合。SOS还与配体激活的酪氨酸激酶受体结合Grb2-Sem-5，以及Grb2-Sem-5结合蛋白Shc有关。果蝇SOS异位表达促进啮齿动物成纤维细胞形态转化这些数据定义了酪氨酸激酶通过RAS控制细胞生长和分化的途径。
The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.