Beta-adrenergic binding is increased by melatonin and alpha-adrenergic compounds.
Beta-adrenergic binding is increased by melatonin and alpha-adrenergic compounds.
复制标题
褪黑激素和α-肾上腺素能化合物可增强β-肾上腺素能结合。
DOI：
10.1016/s0006-291x(86)80409-0
复制
发表时间：
1986
影响因子：
3.1
通讯作者：
Negus,NC
中科院分区：
文献类型：
--
作者：
Sweat,FW;Gower,BA;Berger,PG;Negus,NC
通过加入低浓度褪黑激素、α-肾上腺素能激动剂或α-肾上腺素能拮抗剂，β-肾上腺素能配体[3 H]二氢烯丙洛尔和[125 I]-氰基吲哚洛尔与松果体颗粒组分的结合增加1- 3.5倍。增加β-肾上腺素能结合的褪黑激素或α-肾上腺素能化合物的最小浓度在1 pM和0.1 nM之间。褪黑激素（0.1 μM）引起的[3 H]二氢阿普洛尔结合增加归因于Bmax的大幅增加，在去除褪黑激素后，Bmax仍存在于蛋白质组分中。褪黑激素对[3 H]二氢阿普洛尔结合的增强作用在5至7 min（30°）后明显，在20至40 min之间最佳，并在较长时间内降低。α-肾上腺素能受体在β-受体增强期间不变。
Binding of the β-adrenergic ligands [3H]dihydroalprenolol and [125I]-cyanopindolol to pineal particulate fractions was increased 1- to 3.5-fold by addition of low concentrations of melatonin, α-adrenergic agonists, or α-adrenergic antagonists. Minimum concentrations of melatonin or α-adrenergic compounds which increased β-adrenergic binding were between 1 pM and 0.1 nM. The increased binding of [3H]dihydroalprenolol caused by melatonin (0.1 μM) was attributed to a major increase in Bmax, which persisted in protein fractions after removal of melatonin. Melatonin enhancement of [3H]dihydroalprenolol binding was apparent after 5 to 7 min (30°), was optimal between 20 and 40 min, and decreased at longer times. α-Adrenergic receptors are unchanged during β-receptor enhancement.