Health Behaviors From Early to Late Midlife as Predictors of Cognitive Function The Whitehall II Study
Health Behaviors From Early to Late Midlife as Predictors of Cognitive Function The Whitehall II Study
复制标题
DOI：
10.1093/aje/kwp161
复制
发表时间：
2009-08-15
影响因子：
5
通讯作者：
Singh-Manoux, Archana
中科院分区：
文献类型：
--
作者：
Sabia, Severine;Nabi, Hermann;Singh-Manoux, Archana
作者在白厅II研究（英国）的5，123名男性和女性中检查了17年期间健康行为的关联，分别和组合，以及中年后期的认知。健康行为在中年早期（平均年龄44岁;第1阶段，1985-1988年）、中年（平均年龄56岁;第5阶段，1997-1999年）和中年晚期（平均年龄61岁;第7阶段，2002-2004年）进行评估。不健康行为（吸烟、戒酒、低体力活动、低水果和蔬菜消费）的评分范围为0 - 4。将中年晚期（第7阶段）的执行功能和记忆力差（定义为最差性别特异性五分位数中的评分）作为结局进行分析。与无不良行为者相比，有3-4项不良行为者在第1阶段（比值比（OR）1.84，95%置信区间（CI）：1.27，2.65），5期（OR 2.38，95% CI：1.76，3.22）和7期（OR 2.76，95% CI：2.04，3.73）更可能具有较差的执行功能。在记忆力方面也观察到了类似的联系。参与者在这三个阶段报告不健康行为的次数越多，执行功能和记忆力较差的可能性就越大。这项研究表明，不健康行为的数量和持续时间都与晚年的认知功能有关。
The authors examined associations of health behaviors over a 17-year period, separately and in combination, with cognition in late midlife in 5,123 men and women from the Whitehall II study (United Kingdom). Health behaviors were assessed in early midlife (mean age 44 years; phase 1, 1985-1988), in midlife (mean age 56 years; phase 5, 1997-1999), and in late midlife (mean age 61 years; phase 7, 2002-2004). A score of the number of unhealthy behaviors (smoking, alcohol abstinence, low physical activity, and low fruit and vegetable consumption) was defined as ranging from 0 to 4. Poor (defined as scores in the worst sex-specific quintile) executive function and memory in late midlife (phase 7) were analyzed as outcomes. Compared with those with no unhealthy behaviors, those with 3-4 unhealthy behaviors at phase 1 (odds ratio (OR) 1.84, 95% confidence interval (CI): 1.27, 2.65), phase 5 (OR 2.38, 95% CI: 1.76, 3.22), and phase 7 (OR 2.76, 95% CI: 2.04, 3.73) were more likely to have poor executive function. A similar association was observed for memory. The odds of poor executive function and memory were the greater the more times the participant reported unhealthy behaviors over the 3 phases. This study suggests that both the number of unhealthy behaviors and their duration are associated with subsequent cognitive function in later life.