SCALE-INVARIANT BEHAVIOR AND VASCULAR NETWORK FORMATION IN NORMAL AND TUMOR-TISSUE
SCALE-INVARIANT BEHAVIOR AND VASCULAR NETWORK FORMATION IN NORMAL AND TUMOR-TISSUE
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DOI：
10.1103/physrevlett.75.2428
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发表时间：
1995-09-18
影响因子：
8.6
通讯作者：
JAIN, RK
中科院分区：
文献类型：
--
作者：
GAZIT, Y;BERK, DA;JAIN, RK
肿瘤血管网络看起来与正常血管网络不同，但这些差异背后的机制尚不清楚。通过研究正常血管网络和肿瘤血管网络的尺度不变行为，我们发现血管网络具有三类分形行为。肿瘤网络呈滤过样缩放。正常的动静脉网络显示扩散受限的缩放，正常的毛细血管网络是致密的结构。使用增长模型提出了造成这些差异的机制。
Tumor vascular networks look different from normal vascular networks, but the mechanisms underlying these differences are not known. By studying the scale-invariant behavior of normal and tumor vascular networks we show that vascular networks exhibit three classes of fractal behavior. Tumor networks display percolationlike scaling. Normal arteriovenous networks display diffusion-limited scaling, and normal capillary networks are compact structures. The mechanisms responsible for these differences are suggested using a growth model.