miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers.
miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers.
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DOI：
10.7150/jca.13460
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发表时间：
2016
影响因子：
3.9
通讯作者：
Cheng AJ
中科院分区：
文献类型：
--
作者：
Lu YC;Chang JT;Chan EC;Chao YK;Yeh TS;Chen JS;Cheng AJ
在过去的十年中，microRNA（miRNA）研究的出现已经牢固地确立了这个分子家族作为细胞中的关键组成部分。miRNAs作为负性基因调控因子，参与多种生物学过程，维持细胞内稳态。miRNA的失调可能导致许多人类疾病，包括癌症。近年来发现miR-196在多种恶性肿瘤中异常表达，提示其在肿瘤发生中起重要作用。本文就miR-196家族与肿瘤的关系作一综述。这篇综述包括miR-196基因结构和在各种癌症中的异常表达，以及目前对miR-196在特定癌症中的许多功能和调控靶点的理解。鉴于miR-196在消化道肿瘤组织中的高表达，本文综述了miR-196在消化道肿瘤中的临床意义和应用前景。我们强调miR-196可能作为消化道癌症的新兴癌症生物标志物。
Over the past decade, the emergence of microRNA (miRNA) research has firmly established this molecular family as a key component in cells. MiRNAs, which function as negative gene regulators, participate in multiple biological processes and maintain homeostasis in cells. The dysregulation of miRNA may contribute to numerous human disorders, including cancer. Recently, miR-196 was found to be aberrantly expressed in a wide range of malignant diseases, which suggests that it plays important roles in carcinogenesis. Here, we summarize the current knowledge concerning miR-196 family in cancers. This review includes miR-196 gene structure and aberrant expression in various cancers, and current understanding of numerous functions and regulatory targets of miR-196 in specific cancers. Since miR-196 are consistently found over-expressed in digestive tract cancer tissues, we also reviewed the clinical significance and potential applications of miR-196 in these cancers. We highlight that miR-196 may serve as an emerging cancer biomarker for digestive tract cancers.