Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats.
Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats.
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DOI：
10.3109/10253899609001093
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发表时间：
1996-07
期刊：
影响因子：
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通讯作者：
P. Meerlo;Gerard Overkamp;S. Daan;R. H. Hoofdakker;J. Koolhaas
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文献类型：
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作者：
P. Meerlo;Gerard Overkamp;S. Daan;R. H. Hoofdakker;J. Koolhaas
在一系列实验中，研究了单一和双重社会冲突对大鼠各种行为和体重的影响。通过将动物放入具有攻击性的雄性同种动物的领地一小时（一次或连续两天同时两次），动物会遭受社交失败。为了评估社交失败的后果，对独立的大鼠组进行了三项实验。在第一个实验中，在最后一次冲突两天后进行了露天测试。社交失败后，运动活动大大减少。单败组和双败组之间没有差异。为了评估社交失败对后续社交行为的影响，进行了第二项实验，其中实验动物在一次或两次冲突后两天面对一只不熟悉的非攻击性老鼠。社交失败导致与不熟悉的同类的社交接触减少。单冲突组和双冲突组之间没有差异。在第三个实验中，测量了社会冲突对食物摄入、体重和糖精偏好的影响。单次冲突后，食物摄入量没有受到影响，但在两次冲突中，食物摄入量连续几天减少。在一次和两次社交失败后体重增加均减少。双重冲突组的下降幅度更大。水的摄入量和糖精偏好没有受到显着影响。这项研究表明，老鼠的社交失败会导致各种行为和体重的显着变化。行为的不同方面受到失败的影响，就其引起的变化的幅度和时间进程而言是不同的。此外，不同的行为参数对压力源的重复敏感程度不同。
In a series of experiments, the consequences of a single and double social conflict on various behaviours and body weight in rats were studied. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for one hour, either once, or twice at the same time on two consecutive days. To assess the consequences of social defeat, three experiments were performed with independent groups of rats. In the first experiment, an open field test was performed two days after the last conflict. Locomotor activity was strongly reduced after social defeat. There were no differences between the single and double defeat group. To assess the effects of social defeat on subsequent social behaviour, a second experiment was performed in which experimental animals were confronted with an unfamiliar non-aggressive rat two days after a single or double conflict. Social defeat resulted in a reduction of social contact with the unfamiliar conspecific. There was no difference between the single and double conflict group. In the third experiment, the effects of social conflict on food intake, body weight and saccharine preference were measured. Food intake was not affected after a single conflict, but in the double conflict group food intake was decreased for several days. Body weight gain was decreased after both single and double social defeat. The decrease was stronger in the double conflict group. Water intake and saccharine preference were not significantly affected. This study revealed that social defeat in rats causes pronounced changes in various behaviours and body weight. Different aspects of behaviour are differentially affected by defeat with respect to the magnitude and time course of the changes induced. Moreover, different behavioural parameters are differentially sensitive to repetition of the stressor.