Flexible Piezoresistive Sensor Patch Enabling Ultralow Power Cuffless Blood Pressure Measurement
Flexible Piezoresistive Sensor Patch Enabling Ultralow Power Cuffless Blood Pressure Measurement
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DOI：
10.1002/adfm.201504560
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发表时间：
2016-02-23
影响因子：
19
通讯作者：
Zhao, Ni
中科院分区：
文献类型：
--
作者：
Luo, Ningqi;Dai, Wenxuan;Zhao, Ni
无创、实时无袖带血压测量实现了无创、连续血压监测的理念，对高血压相关心血管疾病的诊断和预防至关重要。本文提出了一种可穿戴传感器贴片系统，该系统集成了柔性压阻传感器（FPS）和表皮心电图（ECG）传感器，用于无袖带血压测量。通过建立FPS传感机制的参数模型和优化操作条件，建立了一种高度稳定的表皮脉搏监测方法，并演示了从ECG和表皮脉搏信号的逐拍BP测量。特别是，这项研究强调了传感器灵敏度和信号稳定性之间的折衷。与当前基于光学的无袖带BP测量设备相比，感测贴片需要低得多的功耗（3 nW），并且能够检测细微的生理信号变化，例如，运动前和运动后，从而为低功耗，实时和基于家庭的BP监测提供了一个有前途的解决方案。
Noninvasive and real-time cuffless blood pressure (BP) measurement realizes the idea of unobtrusive and continuous BP monitoring which is essential for diagnosis and prevention of cardiovascular diseases associated with hypertension. In this paper, a wearable sensor patch system that integrates flexible piezoresistive sensor (FPS) and epidermal electrocardiogram (ECG) sensors for cuffless BP measurement is presented. By developing parametric models on the FPS sensing mechanism and optimizing operational conditions, a highly stable epidermal pulse monitoring method is established and beat-to-beat BP measurement from the ECG and epidermal pulse signals is demonstrated. In particular, this study highlights the compromise between sensor sensitivity and signal stability. As compared with the current optical-based cuffless BP measurement devices, the sensing patch requires much lower power consumption (3 nW) and is capable of detecting subtle physiological signal variations, e.g., pre and postexercises, thus providing a promising solution for low-power, real-time, and home-based BP monitoring.