HOST DEFENSES IN HERPES-SIMPLEX INFECTIONS OF THE NERVOUS-SYSTEM - EFFECT OF ANTIBODY ON DISEASE AND VIRAL SPREAD
HOST DEFENSES IN HERPES-SIMPLEX INFECTIONS OF THE NERVOUS-SYSTEM - EFFECT OF ANTIBODY ON DISEASE AND VIRAL SPREAD
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DOI：
10.1128/iai.23.2.305-311.1979
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发表时间：
1979-01-01
影响因子：
3.1
通讯作者：
BARINGER, JR
中科院分区：
文献类型：
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作者：
MCKENDALL, RR;KLASSEN, T;BARINGER, JR
用单纯疱疹病毒1型[HSV-1]抗体[Ab]被动免疫BALB/c小鼠，并用105.7空斑形成单位的HSV-1在足垫中攻击，与用正常血清或辛德毕斯病毒抗体处理的对照小鼠相比，可保护小鼠免受神经系统疾病和死亡。在未处理的小鼠中，100%的病毒在感染后48小时从背根神经节中恢复。而在48小时截肢的感染肢体没有影响，抗体管理（导致滴度为1：8和1：16）预防急性神经系统疾病，如果不晚于感染后48小时给药。Ab限制了腰骶神经节潜伏感染的范围。Ab在防止病毒在周围神经系统和CNS（脊髓）组织中传播方面显然是有效的。
BALB/c mice passively immunized with antibody [Ab] to herpes simplex virus type 1 [HSV-1] and challenged in the footpad with 105.7 plaque-forming units of HSV-1 were protected from neurological disease and death compared with control mice treated with normal serum or Ab to Sindbis virus. Of untreated mice, 100% had virus recoverable from dorsal root ganglia by 48 h after infection. Whereas amputation of the infected limb at 48 h had no effect, Ab administration (resulting in titers of 1:8 and 1:16) prevented acute neurological disease if administered no later than 48 h after infection. Ab restricted the extent of latent infection in the lumbosacral ganglia. Ab evidently is effective in preventing spread of virus in the peripheral nervous system and in CNS (spinal cord) tissue.