Overview and introduction: the blood-brain barrier in health and disease.
Overview and introduction: the blood-brain barrier in health and disease.
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DOI：
10.1111/j.1528-1167.2012.03696.x
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发表时间：
2012-11
期刊：
影响因子：
5.6
通讯作者：
Friedman A
中科院分区：
文献类型：
--
作者：
Abbott NJ;Friedman A
本文介绍了“血脑屏障与癫痫”的特刊。我们简要回顾了目前对血脑屏障（BBB）的结构和功能的认识，包括其发育和正常生理，以及它在病理学上受到影响的方式。由脑血管内皮形成的血脑屏障是保护中枢神经系统的三大屏障之一。屏障不是刚性结构，而是具有一系列相互关联功能的动态界面，其由极其有效的紧密连接、跨内皮转运系统、酶和白细胞渗透的调节产生，从而产生BBB的物理、转运、酶和免疫调节功能。脑内皮细胞是“模块化”结构（神经血管单位（NVU））的重要组成部分，具有几种相关的细胞类型和细胞外基质成分。现代方法有助于识别一系列参与屏障结构和功能的蛋白质，最近的研究揭示了在BBB发育中重要的重要阶段，细胞类型和信号通路。越来越多的中枢神经系统病理表现出BBB功能障碍，有强有力的证据表明这在某些疾病病因中发挥着重要作用。本期文章将更详细地总结最近在本-古里安大学内盖夫沙漠校区（以色列比尔-舍瓦）举行的“神经功能障碍中的BBB”国际会议的报告和讨论，重点是实验和临床研究之间的联系，以及这些研究导致改善药物治疗的方式。
This article introduces the special issue on “Blood–Brain Barrier and Epilepsy.” We review briefly current understanding of the structure and function of the blood–brain barrier (BBB), including its development and normal physiology, and ways in which it can be affected in pathology. The BBB formed by the endothelium of cerebral blood vessels is one of three main barrier sites protecting the central nervous system (CNS). The barrier is not a rigid structure, but a dynamic interface with a range of interrelated functions, resulting from extremely effective tight junctions, transendothelial transport systems, enzymes, and regulation of leukocyte permeation, which thereby generates the physical, transport, enzymatic, and immune regulatory functions of the BBB. The brain endothelial cells are important components of a “modular” structure, the neurovascular unit (NVU), with several associated cell types and extracellular matrix components. Modern methods have helped in identifying a range of proteins involved in barrier structure and function, and recent studies have revealed important stages, cell types, and signaling pathways important in BBB development. There is a growing list of CNS pathologies showing BBB dysfunction, with strong evidence that this can play a major role in certain disease etiologies. The articles that follow in this issue summarize in more detail reports and discussions of the recent international meeting on “BBB in Neurological Dysfunctions,” which took place recently at Ben-Gurion University of the Negev Desert Campus (Beer-Sheva, Israel), focusing on the link between experimental and clinical studies, and the ways in which these lead to improved drug treatments.
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
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影响因子：
7.8
作者：
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通讯作者：
Dejana, Elisabetta
影响因子：
6.2
作者：
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通讯作者：
Friedman, Alon