The two faces of IL-6 in the tumor microenvironment.
The two faces of IL-6 in the tumor microenvironment.
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IL-6的两个面在肿瘤微环境中。
DOI：
10.1016/j.smim.2014.01.008
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发表时间：
2014-02
影响因子：
7.8
通讯作者：
Evans SS
中科院分区：
文献类型：
--
作者：
Fisher DT;Appenheimer MM;Evans SS
在肿瘤微环境中，IL-6信号通常被认为是一个恶意的参与者，假设一个促进肿瘤进展的黑暗面孔。在许多小鼠模型和人类疾病中，慢性IL-6信号传导与肿瘤发生有关。IL-6本质上通过多种下游介质作用于肿瘤细胞，支持癌细胞增殖、存活和转移传播。此外，IL-6可以作用于复杂肿瘤微环境中的其他细胞，通过支持血管生成和肿瘤逃避免疫监视来维持促瘤环境。最近出现了IL-6信号传导的一个鲜为人知的作用，它发挥了有益的作用，通过动员抗肿瘤T细胞免疫反应来实现肿瘤控制，从而呈现出更公平的一面。越来越多的证据表明，在主动免疫反应中，IL-6在淋巴细胞的激活、增殖和存活中起着关键作用。IL-6信号也可以引起T细胞免疫反应，将其从抑制状态转变为反应状态，从而有效地对抗肿瘤。最后，IL-6在促进T细胞运输到淋巴结和肿瘤部位方面发挥着不可或缺的作用，在那里它们分别有机会被激活并执行它们的细胞毒性效应功能。在这里，我们讨论了肿瘤微环境中IL-6信号的双重面；黝黑的脸会引发恶性肿瘤，而白皙的脸会促进抗肿瘤适应性免疫。
Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is linked to tumorigenesis in numerous mouse models as well as in human disease. IL-6 acts intrinsically on tumor cells through numerous downstream mediators to support cancer cell proliferation, survival, and metastatic dissemination. Moreover, IL-6 can act extrinsically on other cells within the complex tumor microenvironment to sustain a pro-tumor milieu by supporting angiogenesis and tumor evasion of immune surveillance. A lesser known role for IL-6 signaling has recently emerged in which it plays a beneficial role, presenting a fairer face that opposes tumor growth by mobilizing anti-tumor T cell immune responses to attain tumor control. Accumulating evidence establishes IL-6 as a key player in the activation, proliferation and survival of lymphocytes during active immune responses. IL-6 signaling can also resculpt the T cell immune response, shifting it from a suppressive to a responsive state that can effectively act against tumors. Finally, IL-6 plays an indispensable role in boosting T cell trafficking to lymph nodes and to tumor sites, where they have the opportunity to become activated and execute their cytotoxic effector functions, respectively. Here, we discuss the dual faces of IL-6 signaling in the tumor microenvironment; the dark face that drives malignancy, and the fairer aspect that promotes anti-tumor adaptive immunity.
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影响因子：
46.9
作者：
Fischer, M;Goldschmitt, J;RoseJohn, S
通讯作者：
RoseJohn, S
影响因子：
20.3
作者：
Eddahri, Fouad;Denanglaire, Sebastien;Andris, Fabienne
通讯作者：
Andris, Fabienne
影响因子：
120.1
作者：
Drews, J
通讯作者：
Drews, J
DOI：
10.1080/10739680802353850
发表时间：
2009-02
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Chen Q;Appenheimer MM;Muhitch JB;Fisher DT;Clancy KA;Miecznikowski JC;Wang WC;Evans SS
通讯作者：
Evans SS
影响因子：
15.9
作者：
Gao, Sizhi Paul;Mark, Kevin G.;Bromberg, Jacqueline F.
通讯作者：
Bromberg, Jacqueline F.