Effect of renal denervation on release and content of renin in anesthetized dogs.
Effect of renal denervation on release and content of renin in anesthetized dogs.
复制标题
肾去神经支配对麻醉犬肾素释放和含量的影响。
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
Yoshihiro Kaneko
中科院分区：
文献类型：
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作者：
Hideo Ueda;Hitoshi Tagawa;Masao Ishii;Yoshihiro Kaneko
给麻醉犬输注硝普钠，其中1只肾脏去神经，对侧肾脏保留或切除6 ~ 28天，研究降低动脉压对去神经肾脏肾素释放的影响。通过肾静脉和动脉血浆肾素活性的差异来估计肾素释放。对侧肾有神经支配的犬，去神经支配的肾在减压期间无明显的肾素释放，而对侧完整的肾在减压期间有显著的肾素释放；肾素释放在两个肾脏之间的差异非常显著。在双肾神经支配的假手术犬中，两组肾素释放量无显著差异。相比之下，在对侧肾脏切除的狗中，在减压过程中，无神经支配的肾脏出现了显著的肾素释放。在对侧肾完整的狗中，去神经支配肾皮质的肾素含量明显低于对侧神经支配肾皮质。在切除对侧肾脏的狗中，去神经支配肾脏的肾素含量与先前切除的肾脏相比没有下降。讨论了两种情况下失神经肾脏不同反应的可能性。
Sodium nitroprusside was infused into anesthetized dogs, of which one kidney had been denervated and the contralateral kidney had been left untouched or removed 6 to 28 days previously, and effect of reduction of arterial pressure on renin release from the denervated kidney was studied. Renin release was estimated by the difference of renin activity between renal venous and arterial plasma.In dogs with contralateral innervated kidney, there was no significant release of renin from the denervated kidney during reduction in pressure, while there was a marked and significant release from the contralateral intact kidney during the same periods; the difference in renin release between the both kidneys was highly significant. In sham-operated dogs of which both kidneys had been innervated, there was no significant difference in renin release between them. In contrast, in dogs with contralateral kidney removed, a significant release of renin occurred from the denervated kidney during reduction in pressure.In dogs with contralateral intact kidney, renin content of the renal cortex of the denervated kidney was significantly decreased as compared to that of the contralateral innervated kidney. In dogs with contralateral kidney removed, renin content of the denervated kidney did not show a decrease as compared to that of the previously removed kidney. The possibilities for the different response of the denervated kidney between the both situations were discussed.