Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis.
Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis.
复制标题
HLA-Dw16 与亚基马印第安人类风湿性关节炎的关联。
DOI：
10.1002/art.1780340107
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发表时间：
1991
影响因子：
--
通讯作者：
Nepom,BS
中科院分区：
文献类型：
--
作者：
Willkens,RF;Nepom,GT;Marks,CR;Nettles,JW;Nepom,BS
类风湿性关节炎 (RA) 在美洲原住民部落亚基马印第安人中很常见。 HLA-DR4（通常与白种人 RA 相关的 HLA 特异性）在亚基马人中很少见。使用识别与 RA 相关的 DR4 核苷酸序列的特定寡核苷酸探针，在 83% 的 Yakima RA 患者和 60% 的 Yakima 对照受试者中发现了罕见的 HLA-Dw16 基因。该共享序列编码一个离散的 II 类表位，该表位与 DR4 阳性和 DR4 阴性个体中的 RA 高度相关。
Rheumatoid arthritis (RA) is prevalent in Yakima Indians, a Native American tribe. HLA–DR4, the HLA specificity commonly associated with RA in Caucasians, is rare among the Yakima. Using a specific oligonucleotide probe that recognizes DR4 nucleotide sequences associated with RA, a rare HLA–Dw16 gene was identified in 83% of Yakima patients with RA and in 60% of Yakima control subjects. This shared sequence encodes a discrete class II epitope that is highly correlated with RA in both DR4 positive and DR4 negative individuals.