Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease
Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease
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DOI：
10.1253/circj.cj-09-0568
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发表时间：
2010-02-01
影响因子：
3.3
通讯作者：
Wang, Ji-Hung
中科院分区：
文献类型：
--
作者：
Hsu, Bang-Gee;Chen, Yu-Chih;Wang, Ji-Hung
背景：代谢综合征(METS)患者血清脂肪酸结合蛋白4(FABP4)水平升高，探讨FABP4与冠心病(CAD)之间的关系。用国际糖尿病联合会的诊断标准定义METS及其组成部分；50例冠心病患者(51.0%)有METS。空腹FABP_4水平与METS呈正相关(P=0.037)，血清FABP_4水平与多种METS指标呈正相关(P=0.035)。单因素线性回归分析显示，体脂质量(R=0.234；P=0.020)与甘油三酯水平(R=0.348；P
Background: The serum level of fatty-acid-binding protein 4 (FABP4) increases in patients with metabolic syndrome (MetS), so the relationship between FABP4 and MetS among patients with coronary artery disease (CAD) was investigated in the present study.Methods and Results: Fasting blood samples were obtained from 98 CAD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation; 50 CAD patients (51.0%) had MetS. The fasting level of FABP4 positively correlated with MetS (P=0.037) and serum levels of FABP4 correlated with a number of MetS criteria (P=0.035). Univariate linear regression analysis showed that body fat mass (R=0.234; P=0.020) and the levels of triglycerides (R=0.348; P