The cells of the allergic response - Mast cells, basophils, and eosinophils
The cells of the allergic response - Mast cells, basophils, and eosinophils
复制标题
DOI：
10.1001/jama.278.22.1815
复制
发表时间：
1997-12-10
影响因子：
120.7
通讯作者：
Galli, SJ
中科院分区：
文献类型：
--
作者：
Costa, JJ;Weller, PF;Galli, SJ
肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞一直被认为是过敏性疾病中重要的效应细胞。事实上，人们认为细胞的细胞质颗粒相关或脂质介质有助于这些疾病的许多特征性体征和症状。肥大细胞，嗜碱性粒细胞和嗜酸性粒细胞也可能有助于保护性宿主反应，特别是对寄生虫。此外，最近的证据表明，肥大细胞，嗜碱性粒细胞和嗜酸性粒细胞可以分泌广泛的细胞因子，并在某些情况下，表达的功能，可能允许他们调节过敏反应的发展或延续。因此，肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞可以表达免疫调节活性，以及充当效应细胞。
Mast cells, basophils, and eosinophils have long been regarded as important effector cells in allergic disorders. Indeed, it is thought that the cells' cytoplasmic granule-associated or lipid mediators contribute to many of the signs and symptoms that are characteristic of these diseases. Mast cells, basophils, and eosinophils also probably contribute to protective host responses, especially to parasites. In addition, recent evidence shows that mast cells, basophils, and eosinophils can secrete a wide spectrum of cytokines and, in some cases, express functions that may permit them to regulate the development or perpetuation of allergic responses. Thus, mast cells, basophils, and eosinophils may express immunoregulatory activities, as well as serve as effector cells.