Characterization of the Changuinola serogroup viruses (Reoviridae: Orbivirus).
Characterization of the Changuinola serogroup viruses (Reoviridae: Orbivirus).
复制标题
Changuinola 血清群病毒（呼肠孤病毒科：Orbivirus）的特征。
DOI：
10.1159/000149501
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发表时间：
1984
期刊：
影响因子：
4.6
通讯作者：
Knudson,DL
中科院分区：
文献类型：
--
作者：
TravassosdaRosa,AP;Tesh,RB;Pinheiro,FP;TravassosdaRosa,JF;Peralta,PH;Knudson,DL
对24株Changuinola血清群病毒的抗原性、生物学和化学特性进行了研究。病毒对氯仿有抗性，脑内接种对新生仓鼠有致死作用。原型Changuinola病毒株（BT-436）在蚊子和白蛉细胞培养物中复制。在补体结合试验中，病毒广泛的交叉反应和难以区分的，但通过中和试验至少12个不同的血清型被确定，并通过PAGE的双链RNA 22个不同的配置文件被发现。这些数据表明，Changuinola血清组可能是由大量的遗传不同的病毒。还简要回顾了昌吉诺拉血清组病毒的自然史。
The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable; but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.