RESPONSE TO DRUG-THERAPY IN CROHNS-DISEASE - EVALUATION BY RECTAL BIOPSY AND MUCOSAL CELL COUNTS
RESPONSE TO DRUG-THERAPY IN CROHNS-DISEASE - EVALUATION BY RECTAL BIOPSY AND MUCOSAL CELL COUNTS
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DOI：
10.1097/00004836-198404000-00005
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发表时间：
1984-01-01
影响因子：
2.9
通讯作者：
SOMMERS, SC
中科院分区：
文献类型：
--
作者：
KORELITZ, BI;SOMMERS, SC
在38例乙状结肠镜检查有直肠疾病证据的患者中评价了药物治疗后克罗恩病的改善，这些患者的直肠后来表现正常。治疗前后取直肠活检组织进行组织病理学检查。固有层结缔组织细胞的细胞计数用于评价粘膜变化。明显负责直肠粘膜外观恢复正常的药物是柳氮磺胺吡啶、泼尼松和6-巯基嘌呤。
Improvement in Crohn's disease after drug therapy was evaluated in 38 patients with evidence of rectal disease at sigmoidoscopy in whom the rectum later appeared normal. Rectal biopsies taken before and after therapy were examined histopathologically. Cell counts of the lamina propria connective tissue cells were used to evaluate mucosal changes. The drugs apparently responsible for conversion of the rectal mocosal appearance to normal were sulfasalazine, prednisone, and 6-mercaptopurine.