Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD
Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD
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DOI：
10.1186/s12931-019-1059-1
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发表时间：
2019-05-08
影响因子：
5.8
通讯作者：
Hansel, Nadia N.
中科院分区：
文献类型：
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作者：
Fawzy, Ashraf;Anderson, Julie A.;Hansel, Nadia N.
背景：在普通人群和老年人中，血小板计数是一个预后指标。慢性阻塞性肺疾病急性加重期血小板增多症(AECOPD)与死亡率相关；然而，稳定期COPD患者的血小板计数和死亡率之间的关系尚不清楚。方法我们对1797例COPD患者进行了二次抽样后分析，以了解COPD患者的死亡率和发病率。参与者是现在或以前吸烟的人，年龄在40-80岁之间，患有中度COPD，有心血管疾病的病史或风险增加。主要结果是治疗后和治疗后全因死亡率。次要结果包括首次治疗的中/重度AECOPD和治疗中的心血管复合事件(心血管死亡、心肌梗死、中风、不稳定心绞痛和短暂性脑缺血发作)。使用多变量COX比例风险模型来研究研究终点与血小板计数五分位数分组、使用两项分数多项式的连续血小板计数以及低、正常和高血小板计数类别(
BackgroundPlatelet count is a prognostic indicator in the general population and elderly. Thrombocytosis during acute exacerbation of COPD (AECOPD) has been associated with mortality; however, the relationship between platelet count and mortality in stable COPD is unknown.MethodsWe performed post hoc secondary analysis on a subsample of 1797 patients in the Study to Understand Mortality and Morbidity in COPD (SUMMIT) who had blood samples drawn at baseline. Participants were current or former smokers, 40-80years old with moderate COPD and history or increased risk of cardiovascular (CV) disease. The primary outcome was on and post-treatment all-cause mortality. Secondary outcomes included first-on-treatment moderate/severe AECOPD and on-treatment CV composite event (CV death, myocardial infarction, stroke, unstable angina and transient ischemic attack). Multivariable Cox proportional hazards models were used to investigate study endpoint associations with platelet count quintile grouping, continuous platelet count utilizing two-term fractional polynomials, and categories of low, normal and high platelet count (