β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels
β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels
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DOI：
10.1016/j.plefa.2014.05.007
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Bazinet, Richard P.
中科院分区：
文献类型：
--
作者：
Chen, Chuck T.;Bazinet, Richard P.
大脑具有独特的多不饱和脂肪酸组成，具有高水平的花生四烯酸和二十二碳六烯酸（DHA），而二十碳五烯酸（EPA）的水平低几个数量级。随着越来越多的证据表明，脂肪酸进入大脑不是选择性的，事实上，DHA和EPA进入大脑的速度相似，需要新的机制来解释它们在大脑中的巨大浓度差异。在这里，我们总结了最近的研究表明，EPA是迅速和广泛的β-氧化后进入大脑。尽管与使用葡萄糖相比，EPA的β-氧化产生的ATP较低，但脂肪酸β-氧化可在缺乏选择性转运的情况下调节脑脂肪酸水平。此外，当EPA的β-氧化被阻断时，EPA的去饱和增加，土地的再循环减少，以维持低EPA水平。(C)2014爱思唯尔有限公司版权所有。
The brain has a unique polyunsaturated fatty acid composition, with high levels of arachidonic and docosahexaenoic acids (DHA) while levels of eicosapentaenoic acid (EPA) are several orders of magnitude lower. As evidence accumulated that fatty acid entry into the brain was not selective and, in fact, that DHA and EPA enter the brain at similar rates, new mechanisms were required to explain their large concentration differences in the brain. Here we summarize recent research demonstrating that EPA is rapidly and extensively beta-oxidized upon entry into the brain. Although the ATP generated from the beta-oxidation of EPA is low compared to the use of glucose, fatty acid beta-oxidation may serve to regulate brain fatty acid levels in the absence of selective transportation. Furthermore, when beta-oxidation of EPA is blocked, desaturation of EPA increases and Land's recycling decreases to maintain low EPA levels. (C) 2014 Elsevier Ltd. All rights reserved.