Hypertension produced by reductions in uterine perfusion in the pregnant rat - Role of interleukin 6
Hypertension produced by reductions in uterine perfusion in the pregnant rat - Role of interleukin 6
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DOI：
10.1161/01.hyp.0000238442.33463.94
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发表时间：
2006-10-01
期刊：
影响因子：
8.3
通讯作者：
Granger, Joey P.
中科院分区：
文献类型：
--
作者：
Gadonski, Giovani;Babbette, B.;Granger, Joey P.
本研究的目的是确定白细胞介素（IL）6介导的作用，在动脉压（AP）的增加，在子宫灌注压（RUPP）的慢性下降反应在怀孕大鼠。RUPP大鼠的AP（138 +/- 1 mm Hg）高于正常妊娠（NP）大鼠（104 +/- 1转Hg）。RUPP大鼠的血清IL-6水平为104.5 +/- 28.6 pg/mL，而NP大鼠为36.6 +/- 7.4 pg/mL。为了确定血浆IL-6升高2至3倍对妊娠大鼠肾功能和AP的长期影响，我们从妊娠第14天开始向NP大鼠输注IL-6 5天（2.5 ng/天）。5天后，对照NP大鼠的血清IL-6水平为55.5 +/- 6.5 pg/mL，IL-6处理的NP大鼠的血清IL-6水平为157.0 +/- 36.1 pg/mL。在妊娠第19天，与NP对照组（101 ± 1转Hg）相比，IL-6处理的NP大鼠（115 ± 3 mm Hg）的AP更高。IL-6处理的NP大鼠的肾血浆流量和GFR低于NP组。IL-6增加血浆肾素活性，但不影响内皮素在IL-6治疗的NP大鼠。与NP大鼠相反，IL-6对未孕大鼠的AP或肾血流动力学没有影响。总之，这些数据表明，血浆IL-6升高，以响应长期减少子宫灌注在妊娠大鼠和血浆IL-6的相当的升高增加AP和降低肾功能在妊娠大鼠。
The purpose of this study was to determine the role of interleukin (IL) 6 in mediating the increase in arterial pressure (AP) in response to chronic reductions in uterine perfusion pressure (RUPP) in pregnant rats. AP was higher in RUPP rats (138 +/- 1 mm Hg) than in normal pregnant (NP) rats (104 +/- 1 turn Hg). Serum IL-6 levels in the RUPP rats were 104.5 +/- 28.6 pg/mL as compared with 36.6 +/- 7.4 pg/mL in NP rats. To determine the long-term effects of a 2- to 3-fold elevation in plasma IL-6 on renal function and AP in pregnant rats, we infused IL-6 for 5 days (2.5 ng/day) in NP rats starting at day 14 of gestation. Five days later, serum IL-6 levels were 55.5 +/- 6.5 pg/mL in the control NP rats and 157.0 +/- 36.1 pg/mL in the IL-6-treated NP rats. AP was higher in the IL-6-treated NP rats (115 +/- 3 mm Hg) as compared with NP controls (101 +/- 1 turn Hg) at day 19 of gestation. Renal plasma flow and GFR were lower in the IL-6-treated NP rats than in the NP group. IL-6 increased plasma renin activity but did not affect endothelin in IL-6-treated NP rats. In contrast to the NP rats, IL-6 had no effect on AP or renal hemodynamics in virgin rats. In summary, these data indicate that plasma IL-6 is elevated in response to chronic reductions in uterine perfusion in pregnant rats and that a comparable elevation in plasma IL-6 increases AP and reduces renal function in pregnant rats.