Optical Mapping of Virtual Electrode Polarization Pattern and Its Relationship with Pacemaker Location during Gastric Pacing.
Optical Mapping of Virtual Electrode Polarization Pattern and Its Relationship with Pacemaker Location during Gastric Pacing.
复制标题
胃起搏过程中虚拟电极偏振模式的光学映射及其与起搏器位置的关系。
DOI：
10.1109/embc40787.2023.10340002
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Rogers,JackM
中科院分区：
文献类型：
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作者：
Zhang,Hanyu;Patton,HaleyN;Nagahawatte,NipuniD;Athavale,OmkarN;Walcott,GregoryP;Cheng,LeoK;Rogers,JackM
胃节律性收缩由称为慢波（SW）的生物电事件调节。SW活性异常与胃动力障碍有关。胃起搏是恢复节律性SW活动的潜在治疗方法。然而，迄今为止，胃起搏的疗效不一致，胃起搏的潜在机制知之甚少。光学标测广泛应用于心脏电生理学研究。它对起搏伪影的免疫力提供了一个明显的优势，超过传统的电标测研究起搏。在本研究中，我们首先发现光学标测可以成像胃中起搏诱导的虚拟电极极化模式（去极化和超极化组织的相邻区域）。其次，我们发现，引发SW通常（15 16）起源于刺激区域（虚拟阴极）的去极化区。据我们所知，这是第一次直接观察胃中的虚拟电极极化模式。结论：光学标测可以在胃起搏过程中以高空间分辨率成像虚拟电极极化模式。临床相关性-胃起搏是胃动力障碍的潜在治疗方法。本研究提供了胃起搏过程中虚拟电极极化模式的直接观察，并提高了我们对胃起搏机制的理解。
Gastric rhythmic contractions are regulated by bioelectrical events known as slow waves (SW). Abnormal SW activity is associated with gastric motility disorders. Gastric pacing is a potential treatment method to restore rhythmic SW activity. However, to date, the efficacy of gastric pacing is inconsistent and the underlying mechanisms of gastric pacing are poorly understood. Optical mapping is widely used in cardiac electrophysiology studies. Its immunity to pacing artifacts offers a distinct advantage over conventional electrical mapping for studying pacing. In the present study, we first found that optical mapping can image pacing-induced virtual electrode polarization patterns in the stomach (adjacent regions of depolarized and hyperpolarized tissue). Second, we found that elicited SWs usually (15 of 16) originated from the depolarized areas of the stimulated region (virtual cathodes). To our knowledge, this is the first direct observation of virtual electrode polarization patterns in the stomach. Conclusions: Optical mapping can image virtual electrode polarization patterns during gastric pacing with high spatial resolution.Clinical Relevance— Gastric pacing is a potential therapeutic method for gastric motility disorders. This study provides direct observation of virtual electrode polarization pattern during gastric pacing and improves our understanding of the mechanisms underlying gastric pacing..