Deleterious effects of chronic clenbuterol treatment on endurance and sprint exercise performance in rats
Deleterious effects of chronic clenbuterol treatment on endurance and sprint exercise performance in rats
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DOI：
10.1042/cs19990069
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发表时间：
2000-03-01
期刊：
影响因子：
6
通讯作者：
Lynch, GS
中科院分区：
文献类型：
--
作者：
Duncan, ND;Williams, DA;Lynch, GS
β（2）-肾上腺素能激动剂克伦特罗具有强大的肌肉合成代谢和脂肪分解作用，被运动员用于提高运动表现;然而，其与不同形式的运动训练结合使用受到的关注有限。由于先前的研究已经报道，长期使用其他β（2）-肾上腺素能激动剂对心肌结构和功能有有害影响，本研究的目的是确定慢性克伦特罗给药是否会降低长期跑步机短跑，耐力游泳或自愿轮跑训练大鼠的运动能力。在三项独立的研究中评估了克伦特罗治疗对大鼠运动表现的影响。将不同组的雄性大鼠分为耐力游泳（2 h/天，5/7天，18周）组、踏式跑（8 x 1 min bouts，1.05 m/s，20周）组或自愿轮跑（16周）组。在每项研究中，将大鼠分配到接受克伦特罗（2 mg . kg（-1）。第（-1）天）在其饮用水或未处理的对照组中。在三项研究中，与未治疗的大鼠相比，治疗的大鼠表现出运动表现的降低。在自愿跑步计划中，治疗组大鼠的总距离比未治疗组大鼠少57%，并且无法完成未治疗组大鼠进行的游泳和短跑方案。在每项研究中，给药大鼠均表现出心脏肥大，绝对心脏质量增加约19%，心脏质量相对于体重增加约20%。用克伦特罗治疗的久坐大鼠的心脏在血管周围和左心室壁中表现出广泛的胶原蛋白浸润。结果强烈表明，慢性盐酸克伦特罗管理有害影响大鼠的运动表现，可能是由于心肌结构和功能的改变。
The beta(2)-adrenergic agonist, clenbuterol, has powerful muscle anabolic and lipolytic effects and is used by athletes to improve exercise performance; however, its use in conjunction with different forms of exercise training has received limited attention. Since previous studies have reported that chronic use of other beta(2)-adrenergic agonists has deleterious effects on cardiac muscle structure and function, the aim of the present study was to determine whether chronic clenbuterol administration would reduce the exercise capabilities of rats subjected to long-term treadmill sprint running, endurance swimming or voluntary wheel running training. The effect of clenbuterol treatment on exercise performance in rats was evaluated in three separate studies. Different groups of male rats were assigned to an endurance swimming (2 h/day, 5/7 days, 18 weeks) group, a tread mi II sprint running (8 x I min bouts, 1.05 m/s, 20 weeks) group, or a voluntary wheel running (16 weeks) group. In each study, rats were allocated into either a treated group that received clenbuterol (2 mg . kg(-1) . day(-1)) in their drinking water or an untreated control group. In each of the three studies, treated rats exhibited a reduction in exercise performance compared with untreated rats. Treated rats ran similar to 57% less total distance than untreated rats in the voluntary running programme and were unable to complete the swimming and sprinting protocols performed by the untreated rats. In each of the studies, the treated rats exhibited cardiac hypertrophy, with absolute heart mass increased by similar to 19% and heart mass relative to body mass increased by similar to 20%. The hearts of sedentary rats treated with clenbuterol exhibited extensive collagen infiltration surrounding blood vessels and in the wall of the left ventricle. The results indicate strongly that chronic clenbuterol administration deleteriously affects exercise performance in rats, potentially due to alterations in cardiac muscle structure and function.