Applications of small molecule BMP inhibitors in physiology and disease.
Applications of small molecule BMP inhibitors in physiology and disease.
复制标题
DOI：
10.1016/j.cytogfr.2009.10.021
复制
发表时间：
2009-10
影响因子：
13
通讯作者：
Yu, Paul B.
中科院分区：
文献类型：
--
作者：
Hong, Charles C.;Yu, Paul B.
关键词：
骨形态发生蛋白（BMP）提供了决定细胞命运的关键信号，指定原肠胚形成，胚胎图案，器官发生和各种组织的重塑。最近的研究表明，除了协调发育中的关键事件外，BMP还可以独立于对细胞生长或分化的影响调节某些稳态生理过程。我们最近描述了dorsomorphin的鉴定，dorsomorphin是BMP I型受体的小分子抑制剂，其优先于TGF-β、激活素和TGF-β家族的其他配体抑制BMP信号传导。我们描述了一些策略，使用dorsomorphin及其衍生物作为探针，以评估BMP信号的生理作用。我们还讨论了小分子BMP抑制剂的几个潜在应用，包括干细胞操作，以及骨重建，异位骨化和铁稳态的治疗性修饰。
Bone morphogenetic proteins (BMP) provide critical signals for determining cell fate, specifying gastrulation, embryonic patterning, organogenesis, and the remodeling of diverse tissues. Recent work has suggested that in addition to coordinating pivotal events in development, BMPs may also regulate certain homeostatic physiological processes independently of effects on cell growth or differentiation. We recently described the identification of dorsomorphin, a small molecule inhibitor of BMP type I receptors which inhibits BMP signaling in preference to TGF-β, Activin, and other ligands of the TGF-β family. We describe a number of strategies using dorsomorphin and its derivatives as probes to assess the physiologic roles of BMP signaling. We also discuss several potential applications for small molecule BMP inhibitors, including stem cell manipulation, and the therapeutic modification of bone remodeling, heterotopic ossification, and iron homeostasis.
登录
查看更多内容
影响因子：
16
作者：
Goumans, MJ;Valdimarsdottir, G;ten Dijke, P
通讯作者：
ten Dijke, P
DOI：
10.2106/00004623-200312000-00010
发表时间：
2003-12-01
影响因子：
5.3
作者：
Glaser, DL;Economides, AN;Shore, EM
通讯作者：
Shore, EM
影响因子：
11.4
作者：
Goumans, MJ;Valdimarsdottir, G;ten Dijke, P
通讯作者：
ten Dijke, P
影响因子：
3.7
作者：
Hao J;Daleo MA;Murphy CK;Yu PB;Ho JN;Hu J;Peterson RT;Hatzopoulos AK;Hong CC
通讯作者：
Hong CC
影响因子：
46.9
作者：
Chambers, Stuart M.;Fasano, Christopher A.;Papapetrou, Eirini P.;Tomishima, Mark;Sadelain, Michel;Studer, Lorenz
通讯作者：
Studer, Lorenz