Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in ovarian cancers
Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in ovarian cancers
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DOI：
10.1016/s0304-3835(97)00537-5
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发表时间：
1998-04-10
期刊：
影响因子：
9.7
通讯作者：
Tamaya, T
中科院分区：
文献类型：
--
作者：
Fujimoto, J;Ichigo, S;Tamaya, T
检测卵巢癌细胞的生长、侵袭和转移潜能及肿瘤组织中血小板衍化内皮生长因子(PD-ECGF)及其mRNA的表达。并分析其表达与卵巢癌组织学类型和临床分期的关系。卵巢癌组织中PD-ECGF及其mRNA的表达水平高于正常卵巢组织。更重要的是。卵巢子宫内膜样癌、浆液性囊腺癌和部分III、IV期卵巢癌组织中PD-ECGF及其mRNA表达水平显著升高。因此，在某些卵巢癌中，PD-ECGF可能与晚期卵巢癌新生血管相关。爱思唯尔科学爱尔兰有限公司出版。
The potential of growth, invasion and metastasis of ovarian cancer cells associated with neovascularization, and the expression of platelet-derived endothelial growth factor (PD-ECGF) and its mRNA in ovarian cancers were determined. The relationship between their expression and histopathological types and clinical stages of ovarian cancers was also analyzed. The levels of PD-ECGF and its mRNA were higher in ovarian cancers than in normal ovaries. Furthermore. some endometrioid carcinomas and serous cystadenocarcinomas of the ovary and some ovarian cancers in stages III and IV expressed remarkably high levels of PD-ECGF and its mRNA. Therefore, in some ovarian cancers, PD-ECGF might be related to advanced stages of ovarian cancers associated with neovascularization. Published by Elsevier Science ireland Ltd.