Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.
Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.
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改善血脂、舒张压和肾功能是家庭长寿的潜在因素：对 60 个中国百岁老人家庭的研究
DOI：
10.1038/srep21962
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发表时间：
2016-02-25
影响因子：
4.6
通讯作者：
Kong QP
中科院分区：
文献类型：
--
作者：
He YH;Pu SY;Xiao FH;Chen XQ;Yan DJ;Liu YW;Lin R;Liao XP;Yu Q;Yang LQ;Yang XL;Ge MX;Li Y;Jiang JJ;Cai WW;Kong QP
百岁老人是一个很好的健康老龄化模型。有趣的是，百岁老人的后代更容易长寿。本研究以60个长寿家系为研究对象，通过对家族成员血液生化指标的调查，寻找与家族长寿相关的候选因素。首先，检验血液指标与年龄的关系。其次，分析了百岁老人（CEN）与其第一代后代（F1）和F1配偶（F1 SP）的血液参数的相关性。第三，研究了参与调节靶因子的基因。结果表明，总胆固醇（TC）和甘油三酯（TG）随年龄增长而升高，而CEN组则呈下降趋势。同样，血尿素氮（BUN）和血肌酐（BCr）随年龄（20-80岁）而增加，但在CEN中维持在平台期。重要的是，我们首次发现了血压的双重变化，即，CEN组舒张压降低，收缩压升高，这与CST 3表达改变有关。遗传分析表明，CEN的血尿酸（BUA）和BCr与F1显著相关，但与F1 SP不相关，表明它们可能是可遗传性状。总之，我们的研究结果表明，CEN或其后代的血脂，肾功能，尤其是舒张压而不是收缩压得到改善，这表明这些因素可能在家族长寿中发挥重要作用。
Centenarians are a good healthy aging model. Interestingly, centenarians’ offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20–80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20–80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure were improved in CEN or their offspring, suggesting these factors may play an important role in familial longevity.