Cold-adapted recombinant influenza A virus vaccines in seronegative young children.
Cold-adapted recombinant influenza A virus vaccines in seronegative young children.
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血清阴性幼儿的冷适应重组甲型流感病毒疫苗。
DOI：
10.1093/infdis/146.1.71
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Karzon,DT
中科院分区：
文献类型：
--
作者：
Wright,PF;Okabe,N;McKeeJr,KT;Maassab,HF;Karzon,DT
在田纳西州纳什维尔的范德比尔特儿童医院，对21名血清阴性的幼儿进行了两种经鼻注射的减毒活流感病毒疫苗的评估。这些疫苗是冷适应主毒株A/Ann Arbor/6/60病毒的衍生物，含有两个当代毒株A/Hong Kong/123/77(H1N1)或A/Alaska/6/77(H3N2)之一的血凝素和神经氨酸酶。两种疫苗株都在血清阴性的幼儿身上复制，没有遗传不稳定的证据。此外，这两种疫苗株都没有引起可识别的临床反应，不会传染给其他血清阴性的儿童，并提供了持久的免疫力。在随后自然发生的甲型流感/曼谷(H3N2)病毒流行中，根据再次感染的血清学证据，以前接种过相关毒株--甲型流感/阿拉斯加(H3N2型)病毒的儿童得到了显著保护。
Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.