REPEATED ELECTROCONVULSIVE SHOCK PREVENTS INCREASED NEOCORTICAL BETA-1-ADRENOCEPTOR BINDING AFTER DSP-4 TREATMENT IN RATS
REPEATED ELECTROCONVULSIVE SHOCK PREVENTS INCREASED NEOCORTICAL BETA-1-ADRENOCEPTOR BINDING AFTER DSP-4 TREATMENT IN RATS
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DOI：
10.1016/0014-2999(87)90365-7
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发表时间：
1987-02-24
影响因子：
5
通讯作者：
GOODWIN, GM
中科院分区：
文献类型：
--
作者：
DOOLEY, DJ;HEAL, DJ;GOODWIN, GM
对预先注射去甲肾上腺素能神经毒素DSP-4（N-（2-氯乙基）-N-乙基-2-溴苄胺盐酸盐）的大鼠进行重复电休克（ECS）。由去甲肾上腺素消耗引起的新皮质β 1-肾上腺素受体结合的正常增加被ECS有效地阻止。这一发现表明β 1-肾上腺素受体的可塑性可能部分地不依赖于内源性去甲肾上腺素浓度。此外，功能性去甲肾上腺素能神经元不一定是人体电休克治疗抗抑郁作用的关键要求。
Repeated electroconvulsive shock (ECS) was administered to rats previously injected with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride), a noradrenergic neurotoxin. The normal increase in neocortical .beta.1-adrenoceptor binding caused by noradrenaline depletion was effectively prevented by ECS. This finding suggests that the plasticity of the .beta.1-adrenoceptor may be partially independent of endogenous noradrenaline concentration. Additionally, functional noradrenergic neurons are not necessarily a critical requirement for the antidepressant effect of electroconvulsive treatment in humans.